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Regulating the Regulators [PDF]
Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (T) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology ( Hori et ...
Powrie, F, Maloy, K
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CK2 and PML: Regulating the Regulator [PDF]
The PML protein induces senescence, and, upon oncogenic stress, its absence promotes cellular transformation. In this issue of Cell, Scaglioni et al. (2006) show that phosphorylation of PML by CK2, a kinase frequently activated in human cancers, promotes PML degradation.
Lallemand-Breitenbach, V., de Thé, H.
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The British government has plans for a new council to oversee the eight statutory regulators of health professionals (see box). The plans went out for consultation in the summer1 and are included in a bill currently before parliament.2 Proposals for the new overarching council were mooted in the NHS plan and backed by the recent Kennedy report into ...
Steve, Dewar, Belinda, Finlayson
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Immunoproteasomes: Regulating the regulator [PDF]
I f proteins were people, half of the world's population (3 × 109) would cohabit, cheek by jowl, the typically sized vertebrate cell. Proteins are the most abundant macromolecular constituent of cells and certainly the most important and interesting. Because the interactions of proteins with each other and other cellular components are governed by the ...
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To regulate or not to regulate—That is the question [PDF]
Mark Gorney, MD, Napa, CA , is a board-certified plastic surgeon ana an ASAPS member. He serves on the Board of Governors of The Doctors' Company of California, the nation's largest doctor-owned malpractice insurance company. He also serves as chairman of the company's Risk Management Committee and is Consulting Medical Director.
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Regulating the Regulators [PDF]
Regulatory reform is increasingly centred around mechanisms of systematic review processes which ‘regulate the regulators’, These meta-regulatory regimes shift the balance in regulation-making from politicans and parliament to economists in the central agencies of government. The article traces the emergence of a new meta-regulatory regime in Australia
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SUMO: regulating the regulator.
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review
Bossis, G., Melchior, F.
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As the 2008 Financial Crisis caused global markets to contract, and people across the United States and the world suffered the costs, there has been a growing and significant body of literature investigating the relative culpability of different financial actors and institutions in perpetrating the 2008 crisis.
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“Emotional regulation” or “affective regulation”?
In recent decades, there has been an increased interest in psychology to understand the emotional experience. This growing interest has led to a proliferation of terms, among which regulation, intelligence, and emotional competence stand out. Research in these areas has facilitated a better understanding of what emotion entails and how to intervene in ...
De Jesús Gómez, Ruth +1 more
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The regulators and the regulated [PDF]
It is far too early to make any final assessment of what has been happening at the Environmental Protection Agency these past few weeks. The resignation of Administrator Anne Burford and the firing of other senior agency officials are only the outward manifestations of the bigger issue of this Administration's attitude toward the environment.
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