Results 221 to 230 of about 1,609,140 (304)

BOLD-100 treatment induces systemic lipid crosstalk in metastatic colorectal carcinoma patients in a combination treatment with FOLFOX. [PDF]

iScience
Borutzki Y, Hagn G, Bileck A, Mohr T, Bazett M, Snow M, Jones M, Pankovich J, Gerner C, Keppler BK, Meier-Menches S.   +10 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Corrigendum to "Unit inconsistency in forensic blood and breath alcohol reporting" [Forensic Sci. Int.: Synergy 12 (2026) 100674]. [PDF]

Forensic Sci Int Synerg
Olson A.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Cross-disciplinary "General Learning Objectives" for postgraduate medical training: Prioritisation of five competency domains using a Delphi process. [PDF]

GMS J Med Educ
Bayha E, Armstad H, Spinas G, Brodmann Maeder M, Hennel EK.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

"Ethics Committee Approval and Participant Consent Were Not Required": Challenging a Persistent Misconception in Biomedical Research. [PDF]

Indian J Psychol Med
Bipeta R.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

MOREshiny: a user-friendly application for the inference of phenotype-specific multi-omic regulatory networks. [PDF]

Bioinform Adv
Aguerralde-Martin M, Moldovan RA, Verdú M, Tarazona S.   +3 more
europepmc   +1 more source