Results 241 to 250 of about 1,609,140 (304)

China's regulatory regime for medical biotechnology: evolution, challenges, and future perspectives. [PDF]

Front Med Technol
Zhang E.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Casting light on the workings of illegal fishing markets. [PDF]

Proc Natl Acad Sci U S A
Le Billon P, Ladefoged Z, Sumaila UR.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The Relevance of Law and Economics for Fire Safety. [PDF]

Fire Technol
Korsten R, Franchini A, Van Coile R.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The impact of Shanghai's comprehensive smoke-free legislation on hospital admission and mortality rates for chronic obstructive pulmonary disease: an interrupted time series analysis. [PDF]

Nicotine Tob Res
Sun L, Qin D, Chen, Yu H, Shi Y, Hu Y, Gao J, Xie C, Chen X, Wang H.   +9 more
europepmc   +1 more source

Fast Food, Health Impacts, and Policy Responses in China and India. [PDF]

Ann Glob Health
Williams A.
europepmc   +1 more source

The International Health Regulations and the imperative to strengthen global health: the case of Brazil. [PDF]

Rev Soc Bras Med Trop
Garcia MHO, Maciel EL, Lima NT.
europepmc   +1 more source

The Current Status of the 3Rs Principles in Animal Use in Bosnia and Herzegovina: Overview and Future Perspectives. [PDF]

Animals (Basel)
Smajlhodžić-Deljo M, Pehlivanović Kelle B, Elezović A, Bejdić P, Dervišević A, Kitsara M, Neuhaus W.   +6 more
europepmc   +1 more source