Results 231 to 240 of about 4,194,617 (361)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Proposed Legislation on Short Term Time Off in the 108th Congress [PDF]

, 2005
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Summary Comparison of Select Foreign EXTO Laws [PDF]

, 2006
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

A call for congressional action: revisiting the U.S. coordinated framework for the regulation of biotechnology. [PDF]

Front Bioeng Biotechnol
Buchman L, Kovak E.
europepmc   +1 more source

Cardiac vagal regulation in infancy predicts executive function and social competence in preschool: Indirect effects through language

, 2018
Margaret Whedon, Nicole B. Perry, Susan D. Calkins, Martha Ann Bell   +3 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Eligibility for Medical & Family Leave Under the FMLA: Development of the Statutory Text 1985-1993 [PDF]

, 2005
Workplace Flexibility 2010, Georgetown University Law Center
core   +1 more source

Consumer protection in financial services – towards greater transparency with a key information document for packaged retail investment products

Wroclaw Review of Law, Administration and Economics, 2012
Kozłowska Maja
doaj   +1 more source

Microbiological quality of drinking water from water dispensers. [PDF]

AIMS Microbiol
Hile TD, Leal R, Dunbar SG, Sinclair RG.
europepmc   +1 more source