Results 1 to 10 of about 6,034,940 (339)

Digital Innovation in Medicinal Product Regulatory Submission, Review, and Approvals to Create a Dynamic Regulatory Ecosystem—Are We Ready for a Revolution?

Frontiers in Medicine, 2021
The pace of scientific progress over the past several decades within the biological, drug development, and the digital realm has been remarkable. The’omics revolution has enabled a better understanding of the biological basis of disease, unlocking the ...
Judith C. Macdonald, David C. Isom, Daniel D. Evans, Katy J. Page   +3 more
doaj   +1 more source

Surfactants, Nanomedicines and Nanocarriers: A Critical Evaluation on Clinical Trials

Pharmaceutics, 2021
Advances, perspectives and innovation in drug delivery have increased in recent years; however, there is limited information available regarding the actual presence of surfactants, nanomedicines and nanocarriers in investigational medicinal products ...
Diego Alejandro Dri, Carlotta Marianecci, Maria Carafa, Elisa Gaucci, Donatella Gramaglia   +4 more
doaj   +1 more source

Regulatory squelching [PDF]

FEBS Letters, 1994
An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle‐dependent and differentiation‐specific ...
Cahill, Michael A., Ernst, Wolfram H., Janknecht, Ralf, Nordheim, Alfred   +3 more
openaire   +2 more sources

Purchase Intent and Product Appeal of Velo Nicotine Pouches Among Current Tobacco Users and Nonusers of Tobacco

Contributions to Tobacco and Nicotine Research, 2023
Oral nicotine pouches is a rapidly growing product category that potentially offers less risk than combustible tobacco products. Nicotine pouches may provide harm reduction for smokers because they contain no tobacco and have reduced harmful constituents
Freeland Robert E., Battista Deena R., Polster Michael, Chae Robyn, Dianno Nicole, Frost-Pineda Kimberly   +5 more
doaj   +1 more source

Online Information on Probiotics: Does It Match Scientific Evidence?

Frontiers in Medicine, 2020
Probiotics are over-the-counter products marketed for enhancing human health. Online information has been key in promoting probiotics worldwide. However, only few rigorous clinical studies have met the stringent criteria required to establish the ...
Marie Neunez, Michel Goldman, Pietro Ghezzi   +2 more
doaj   +1 more source

Effects of Hyperbaric Oxygen on T helper 17/regulatory T Polarization in Antigen and Collagen-induced Arthritis: Hypoxia-inducible Factor-1α as a Target

Oman Medical Journal, 2020
Objectives: We sought to investigate and prove the effect of hyperbaric oxygen therapy (HBOT) on T helper 17 (Th17)/regulatory T (Treg) cell polarization through changes in the expression of hypoxia-inducible factor-1 alpha (HIF-1α) in rheumatoid ...
Titut Harnanik, Joewono Soeroso, Mohammad Guritno Suryokusumo, Tedy Juliandhy   +3 more
doaj   +1 more source

Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios− Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals

Frontiers in Immunology, 2021
CD4 Tregs are involved in the regulation of various autoimmune diseases but believed to be highly heterogeneous. Studies have indicated that Helios controls a distinct subset of functional Tregs.
Yuyue Zhang, Jie Zhang, Yun Shi, Min Shen, Hui Lv, Shu Chen, Yingjie Feng, Heng Chen, Xinyu Xu, Tao Yang, Kuanfeng Xu   +10 more
doaj   +1 more source

Molecular characterization of adenosine monophosphate deaminase 1 and its regulatory mechanism for inosine monophosphate formation in triploid crucian carp

Frontiers in Physiology, 2022
Inosine monophosphate (IMP) is the main flavoring substance in aquatic animal, and adenosine monophosphate deaminase1 (AMPD1) gene is a key gene in IMP formation.
Yonghua Zhou, Anli Zuo, Yingjie Li, Yu Zhang, Zilin Yi, Dafang Zhao, Jianzhou Tang, Fufa Qu, Shenping Cao, Zhuangwen Mao, Junyan Jin, Zhen Liu   +11 more
doaj   +1 more source

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019

Pharmaceutics, 2020
Lack of age-appropriate commercially drug products availability is a common problem in pediatric therapeutics; this population needs improved and safer drug delivery.
Jose-Manuel delMoral-Sanchez, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez, Andres Navarro-Ruiz, Marival Bermejo   +4 more
doaj   +1 more source

Analisis Perubahan Ketiga Undang-Undang Mahkamah Konstitusi Ditinjau dari Perspektif Pembentukan Peraturan Perundang-Undangan Di Indonesia

Ajudikasi, 2022
The third amendment to the Constitutional Court Act drew a lot of criticism, especially regarding the urgency of the change, considering that the Constitutional Court Law is not included in the priority prolegnas in 2020.
Ahmad Yusup
doaj   +1 more source