Results 71 to 80 of about 449,254 (259)

Current status of xenotransplantation from an immunobiological standpoint

Clinical transplantation and research
Xenotransplantation, which involves the transplantation of organs, tissues, or cells from animals into humans, is emerging as a promising solution to mitigate the global shortage of human donor organs. Nonetheless, its clinical application is constrained
Jae-Yun Ko, Geon Lee, Hyun Woo Kim, Minji Kang, Hyun Je Kim, C. Park   +5 more
semanticscholar   +1 more source

Moving through the Stressed Genome: Emerging Regulatory Roles for Transposons in Plant Stress Response

Frontiers in Plant Science, 2016
The recognition of a positive correlation between organism genome size with its transposable element (TE) content, represents a key discovery of the field of genome biology.
P. Negi, A. Rai, P. Suprasanna
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Treatment optimisation in patients with functional Class II chronic heart failure and arterial hypertension

Кардиоваскулярная терапия и профилактика, 2012
Aim.To identify the optimal treatment tactics in patients with Functional Class (FC) II chronic heart failure (CHF) (NYHA classification) and essential arterial hypertension (EAH), via investigating the effects of different medication classes on ...
S. G. Kanorskyi, V. G. Tregubov, V. M. Pokrovskyi, N. A. Bulozhenko   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

EFFECT OF STRESS ON DEVELOPMENT OF ABNORMALITIES OF LABOR

Кубанский научный медицинский вестник, 2018
Aim. To study stress factors influence on labor course.Materials and methods. 1542 deliveries of term pregnancies were analyzed, in 425 women the assessment of regulatoryadaptive status on parameters of cardio-respiratory synchronism tests have been ...
M. A. BOLOGOV, G. A. PENJHOYAN
doaj   +1 more source

Unlocking the dual role of LSD1 in tumor immunity: innate and adaptive pathways

Theranostics
The roles of innate and adaptive immunity are crucial in both the development of cancer and its response to treatment. Numerous studies have demonstrated that histone lysine-specific demethylase 1 (LSD1) is overexpressed in various cancers.

semanticscholar   +1 more source

Calculation Algorithm of Tire-Road Friction Coefficient Based on Limited-Memory Adaptive Extended Kalman Filter

Mathematical Problems in Engineering, 2019
In this paper, a limited-memory adaptive extended Kalman Filter (LM-AEKF) to estimate tire-road friction coefficient is proposed. By combining extended Kalman filter (EKF) with the limited-memory filter, this algorithm can reduce the effects of old ...
Bin Huang, Xiang Fu, Sen Wu, Song Huang
semanticscholar   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source