Results 51 to 60 of about 449,254 (259)

REGULATORY ADAPTIVE STATUS IN DETERMING THE EFFECTIVENESS OF ZOFENOPRIL AND LISINOPRIL IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION

Medical Journal of the Russian Federation, 2018
Goal. Сompare the effectiveness of combination therapy with zofenopril and lisinopril in patients with preserved ejection fraction (CHFpEF) of the left ventricle (LV) in the presence of hypertension disease (HD), considering its impact on the regulatory adaptive status (RAS). Material and methods. 69 patients with CHFpEF in the presence of HD III stage
S. N Nedvetskaya, I. Z Shubitidze, V. G Tregubov, V. M Pokrovsky   +3 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Periodontitis pain symdrome influence on regulatiry-adaptive capacity of human organisms

Кубанский научный медицинский вестник, 2014
30 patients with periodontitis have been involved in identification of index of regulatory-adaptive capacity status prior to treatment and after it, and from it they have determined regulatory-adaptive capacity of organisms.
A. O. Serobyan
doaj  

Clinical value of the major types of reactions of the body’s stress-regulating systems in ischemic stroke

Неврология, нейропсихиатрия, психосоматика, 2013
The time course of changes in the parameters reflecting the status of different components of the body’s regulatory systems was studied in 125patients with hemispheric ischemic stroke via comprehensive evaluation of the hypothalamo-pituitary axes and ...
Aleksandr Mikhailovich Dolgov, A Yu Ryabchenko   +1 more
doaj   +1 more source

Associations of innate and adaptive immune cell subsets with incident type 2 diabetes risk: the MESA study.

Journal of Clinical Endocrinology and Metabolism, 2020
OBJECTIVE Cell-mediated immunity is implicated in glucose homeostasis and insulin resistance. Whether the levels of innate and adaptive immune cells in peripheral blood are risk factors for incident type 2 diabetes (T2D) remains unknown.
N. Olson, M. Doyle, C. Sitlani, I. D. de Boer, S. Rich, S. Huber, A. Landay, R. Tracy, B. Psaty, J. Delaney   +9 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

REGULATORY-ADAPTIVE STATUS IN PATIENTS WITH THE II CLASS MALOCCLUSION

Кубанский научный медицинский вестник, 2014
Research of the regulatory-adaptive status with the help of the cardiorespiratory test among 28 patients with the II class malocclusion accompanying bad habits and functional disorders. It is taped that people with the II class malocclussion had decrease
N. I. Chechula, V. M. Pokrovskiy, A. F. Verapatvelyan, M. N. Mitropanova   +3 more
doaj  

An Exploratory Study on Effective Leadership and Change Management in the Transformation of Indonesian Public Universities Towards World-Class University Status

Sustainability
This study aims to examine the influence of leadership styles on institutional transformation and to identify adaptive strategies for effective change management in the context of Indonesian Public Universities (PTNs) striving to achieve world-class ...
Makna Ani Marlia, Rahmi Fahmy, H. Lukito, D. Games   +3 more
semanticscholar   +1 more source