Results 21 to 30 of about 6,202,519 (294)

CTRI - Clicking to greater transparency and accountability

open access: yesPerspectives in Clinical Research, 2012
A clinical trial registry (CTR) is an official platform for registering a clinical trial (CT) with an objective of providing increased transparency and access to CTs to the public at large.
Bobby George
doaj   +1 more source

International Council for Harmonisation E6(R2) addendum: Challenges of implementation

open access: yesPerspectives in Clinical Research, 2017
The International Council for Harmonisation (ICH) E6 – good clinical practice (GCP) (R2) addendum – was released in 2016 to encourage implementation of improved approaches for the management of clinical trials.
Arun Bhatt
doaj   +1 more source

Repair of thermoplastic composites: an overview

open access: yesAdvanced Manufacturing: Polymer & Composites Science, 2022
An extensive review of literature is conducted to present the evolution of the field of repair of thermoplastic composites (TPC’s) from when it was first mentioned in 1980.
J. Barroeta Robles   +3 more
doaj   +1 more source

Principles of regulatory T cell function.

open access: yesImmunity, 2023
Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies.
Stanislav Dikiy, A. Rudensky
semanticscholar   +1 more source

SHARIAH COMPLIANCE ON RETAKAFUL IN MALAYSIA

open access: yesDiponegoro Law Review, 2021
Retakaful is an Islamic alternative to the reinsurance industry in ensuring the stability of takaful companies. In Malaysia, the takaful operators need to depend on retakaful operators to ensure the takaful industry's long-term continuity by sharing the ...
Nurwajihah Ajlaa Ali, Ruzian Markom
doaj   +1 more source

Wholesale price discrimination with regulatory asymmetry [PDF]

open access: yes, 2020
This paper studies the welfare effects of wholesale price discrimination between downstream firms operating under different regulatory systems. I model a monopolistic intermediate good market in which production cost differences between downstream ...
Asseyer, Andreas
core   +1 more source

Chemistry, manufacturing, and controls for live microbial products: addressing classification challenges and enhancing process validation

open access: yesFrontiers in Microbiomes
Traditional process validation life cycles need to be tailored to the specific needs of live microbial products (LMPs). LMPs can be divided into subcategories, and the product characteristics are the basis for the regulatory category and thereby the ...
Ralph Slijkerman   +5 more
doaj   +1 more source

Regulatory T cells and immune tolerance.

open access: yesCell, 2008
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host.
S. Sakaguchi   +3 more
semanticscholar   +1 more source

ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context [PDF]

open access: yesBMC Bioinformatics, 2004
BackgroundElucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for ...
Adam A. Margolin   +6 more
semanticscholar   +1 more source

Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation

open access: yesNature, 2013
Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal ...
Nicholas Arpaia   +10 more
semanticscholar   +1 more source

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