Results 41 to 50 of about 269,212 (236)
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry
STAR Protocols, 2021 Summary: T cells play a key role in adaptive immunity. Defects in specific T cell receptors or signaling proteins can alter their frequency and activation status, which may be associated with immune disease or cancer.
Ioannis Skordos +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Complex assessment of blood pressure regulation system in hypertension patients [PDF]
Research Results in Pharmacology, 2019 Introduction: There are almost no studies characterizing the integrative level of blood pressure (BP) regulation. Materials and methods: 277 people of both genders aged 58.6±6.4 with stage II hypertension disease were randomized into ...
Natalya A. Samorodskaya +2 more
doaj +3 more sources
NR4A1-3 nuclear receptor activity and immune cell dysregulation in rheumatic diseases
Frontiers in Medicine, 2022 The development and progression of immune-mediated rheumatic disease (IMRD) involves dysfunction of innate and adaptive immune cell populations leading to altered responses including inflammasome activation, dysregulated cytokine networks, increased ...
Evelyn P. Murphy, Daniel Crean
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Periodontitis pain symdrome influence on regulatiry-adaptive capacity of human organisms
Кубанский научный медицинский вестник, 2014 30 patients with periodontitis have been involved in identification of index of regulatory-adaptive capacity status prior to treatment and after it, and from it they have determined regulatory-adaptive capacity of organisms.
A. O. Serobyan
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
REGULATORY-ADAPTIVE STATUS IN PATIENTS WITH THE II CLASS MALOCCLUSION
Кубанский научный медицинский вестник, 2014 Research of the regulatory-adaptive status with the help of the cardiorespiratory test among 28 patients with the II class malocclusion accompanying bad habits and functional disorders. It is taped that people with the II class malocclussion had decrease
N. I. Chechula +3 more
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