Results 151 to 160 of about 5,375,401 (399)

Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

bioRxiv, 2018
Regulatory elements, e.g. enhancers and promoters, have been widely reported to be enriched for disease and complex trait heritability. We investigated how this enrichment varies with the age of the underlying genome sequence, the conservation of ...
M. Hujoel, S. Gazal, F. Hormozdiari, Bryce van de Geijn, A. Price   +4 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Engineering Complexity in Bacterial Regulatory Circuits for Biotechnological Applications

mSystems, 2018
Engineering microbial systems allows the generation of new technologies having significant impact in the biotechnological industry and on human health. In the past few years, several synthetic biology approaches have been implemented in bacteria to allow
Cauã Antunes Westmann, María-Eugenia Guazzaroni, Rafael Silva-Rocha   +2 more
doaj   +1 more source

Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease [PDF]

, 2018
Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products.
Alzheimer’s Disease Neuroimaging Initiative, Han, Seonggyun, Horgousluoglu, Emrin, Kim, Dokyoon, Kim, Dongwook, Lee, Younghee, Nho, Kwangsik, Risacher, Shannon L., Saykin, Andrew J.   +8 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

XAF1 promotes osteoclast apoptosis by antagonizing the XIAP-caspase axis

Journal of Orthopaedic Translation
Background: Over-activated osteoclast (OC) is a major cause of diseases related to bone loss and bone metabolism. Both bone resorption inhibition and apoptosis induction of osteoclast are crucial in treating these diseases.
Mingchao Zhang, Yingkang Huang, Jinyu Bai, Wushuang Xu, Huajian Shan, Lei Sheng, Xiang Gao, Yu Han, Shiyou Wang, Chaowen Bai, Bo Tian, Yichao Ni, Qirong Dong, Feng Ma, Xiaozhong Zhou   +14 more
doaj   +1 more source

Putrescine Is an Intraspecies and Interkingdom Cell-Cell Communication Signal Modulating the Virulence of Dickeya zeae

Frontiers in Microbiology, 2019
The infections caused by Dickeya zeae become a severe problem in recent years, but the regulatory mechanisms that govern the bacterial virulence remain to be fragmental.
Zurong Shi, Zurong Shi, Zurong Shi, Qingwei Wang, Yasheng Li, Yasheng Li, Zhibing Liang, Zhibing Liang, Linghui Xu, Jianuan Zhou, Jianuan Zhou, Zining Cui, Zining Cui, Lian-Hui Zhang, Lian-Hui Zhang   +14 more
doaj   +1 more source

The Gate-Resonance Model - The interface of policy, media and the public in technology conflicts [PDF]

The gate/resonance model provides an analytical frame for the description of technology conflicts. It offers an analytical scheme to conceptualise the interaction between public opinion, interest representing organisations, the media and the political ...
Helge Torgersen, Jürgen Hampel
core  

RNA Regulatory Elements and Polyadenylation in Plants [PDF]

Frontiers in Plant Science, 2012
Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. APA may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3'-UTRs (and thus differing regulatory ...
openaire   +3 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source