Results 161 to 170 of about 5,375,401 (399)
The interdependence of gene-regulatory elements and the 3D genome
Journal of Cell Biology, 2018 &NA; Imaging studies, high‐resolution chromatin conformation maps, and genome‐wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression.
M. Vermunt, Di Zhang, G. Blobel
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Frontiers in Plant Science, 2017 Silicon (Si), the quasi-essential element occurs as the second most abundant element in the earth's crust. Biological importance of Si in plant kingdom has become inevitable particularly under stressed environment.
Abinaya Manivannan +2 more
doaj +1 more source
Stepping stones and access holidays: the fallacies of regulatory micro-management [PDF]
Good intentions are no substitute for sound economic regulation. Using the ‘in-vestment ladder’ as the stick and access holidays as the carrot is hardly an ef-fective way to generate competition. On the contrary, this approach creates a regulatory spiral.
Knieps, Günter, Zenhäusern, Patrick
core
Finding regulatory elements and regulatory motifs: a general probabilistic framework [PDF]
BMC Bioinformatics, 2007 Over the last two decades a large number of algorithms has been developed for regulatory motif finding. Here we show how many of these algorithms, especially those that model binding specificities of regulatory factors with position specific weight matrices (WMs), naturally arise within a general Bayesian probabilistic framework. We discuss how WMs are
openaire +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Mutational analysis of structural elements in a class-I cyclic di-GMP riboswitch to elucidate its regulatory mechanism [PDF]
, 2016 Saki Inuzuka +6 more
openalex +1 more source
Reduction of regulatory risk: a network economic approach [PDF]
Several definitions of regulatory risk are known from the literature. From the perspective of regulatory reform it is important to differentiate between the impact of a given regulatory scheme on the firm's risk exposure and the risk arising from ...
Knieps, Günter, Weiß, Hans-Jörg
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Reconstructing Climate Policy: Beyond Kyoto [PDF]
, 2003 In their comprehensive analysis of the Kyoto Protocol and climate policy, Richard B. Stewart and Jonathan B. Wiener examine the current impasse in climate policy and the potential steps nations can take to reduce greenhouse gases.
Stewart, Richard B., Wiener, Jonathan B.
core +2 more sources