Results 181 to 190 of about 5,141,166 (402)

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

Molecules and Cells, 2010
S. Heinz, C. Benner, N. Spann, E. Bertolino, Yin C Lin, P. Laslo, Jason X. Cheng, C. Murre, Harinder Singh, C. Glass   +9 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Dual control of the Bradyrhizobium japonicum symbiotic nitrogen fixation regulatory operon fixR nifA: analysis of cis- and trans-acting elements [PDF]

, 1989
Beat Thöny, Denise Anthamatten, Hauke Hennecke   +2 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Molecular Structure of the Chicken Vitamin D-lnduced Calbindin-D_28KGene Reveals Eleven Exons, Six Ca²⁺-Binding Domains, and Numerous Promoter Regulatory Elements [PDF]

, 1988
Phillip P. Minghetti, M. Leonor Cancela, Yoshiki Fujisawa, Georgia Theofan, Anthony W. Norman   +4 more
openalex   +1 more source

A map of cis-regulatory elements and 3D genome structures in zebrafish

Nature, 2020
Hongbo Yang, Yu Luan, Tingting Liu, H. Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Q. Jin, K. C. Ang, X. Xing, Juan Wang, Jie Xu, F. Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N. K. Choudhary, J. Topczewski, Kai Wang, G. Gerhard, R. Hardison, Ting Wang, K. Cheng, Feng Yue   +25 more
semanticscholar   +1 more source

The Functional Consequences of Variation in Transcription Factor Binding

, 2013
One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in ...
Cusanovich, Darren A., Gilad, Yoav, Pavlovic, Bryan, Pritchard, Jonathan K.   +3 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Human immunodeficiency virus type 2 long terminal repeat: analysis of regulatory elements. [PDF]

, 1988
Suresh K. Arya, R C Gallo
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source