Results 311 to 320 of about 5,375,401 (399)

Exploring the roles of conserved context-dependent cis-regulatory elements (cdCREs) in multicellularity, human health and disease. [PDF]

FEBS J
McEwan A, Rattray A, Hutchings G, Hay E, Murgatroyd C, MacKenzie A.   +5 more
europepmc   +1 more source

Reviewer #2 (Public review): Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

Yao-Chung Chen, Arnaud Maupas, Katja Nowick   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Identification and analysis of functional regulatory elements and RNAi silencing genes in mandarin clementine (Citrus clementina)

Maryam Noor, Iqra Mehar, Hadia Hussain, Abdel‐Rhman Z. Gaafar, Mutwakel Dabiellil, Tawaf Ali Shah   +5 more
openalex   +1 more source

Additional file 12: of Identification and expression analysis of genes with pathogen-inducible cis-regulatory elements in the promoter regions in Oryza sativa

, 2018
Weiwen Kong, Li Ding, Jia Cheng, Bin Wang   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Unproductive alternative splicing of ATM exon 7: mapping of critical regulatory elements and identification of 34 spliceogenic variants. [PDF]

J Mol Med (Berl)
Llinares-Burguet I, Sanoguera-Miralles L, García-Álvarez A, Esteban-Sánchez A, Caloca MJ, de la Hoya M, Bueno-Martínez E, Velasco-Sampedro EA.   +7 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Epigenomic signatures of cis-regulatory elements in the developing mouse and pig forelimb. [PDF]

Sci Data
Sospedra-Arrufat I, Martínez-García PM, Gil-Gálvez A, Alcaina-Caro A, Tena JJ, Nusspaumer G, Lopez-Rios J.   +6 more
europepmc   +1 more source

Additional file 1: of Expression characterization of the herbicide tolerance gene Aryloxyalkanoate Dioxygenase (aad-1) controlled by seven combinations of regulatory elements

, 2018
Delkin O. Gonzalez, Jeffrey S. Church, Andrew P. Robinson, James P. Connell, Megan Sopko, Boyd Rowland, Kristina Woodall, C.A. Larsen, John P. Davies   +8 more
openalex   +1 more source