Results 341 to 350 of about 5,375,401 (399)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Multiscale footprints reveal the organization of cis-regulatory elements. [PDF]

Nature
Hu Y, Horlbeck MA, Zhang R, Ma S, Shrestha R, Kartha VK, Duarte FM, Hock C, Savage RE, Labade A, Kletzien H, Meliki A, Castillo A, Durand NC, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers AJ, Buenrostro JD.   +21 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte development. [PDF]

iScience
Tingvall-Gustafsson J, Jensen CT, Ungerbäck J, Sigvardsson M.   +3 more
europepmc   +1 more source

Cis-regulatory elements co-opting core circadian clock regulator CCA1 underlie enhanced expression of HMA4 for metal hyperaccumulation in Arabidopsis halleri. [PDF]

Plant Commun
Castanedo L, Cebula J, Nouet C, Spielmann J, Janina N, Hanikenne M, Krämer U.   +6 more
europepmc   +1 more source

Wnt signaling activation induces CTCF binding and loop formation at <i>cis</i>-regulatory elements of target genes. [PDF]

Genome Res
Nordin A, Chakraborty C, Jonasson M, Dano O, Zambanini G, Pagella P, Remeseiro S, Cantù C.   +7 more
europepmc   +1 more source

Additional file 6 of ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia

Anwar, Rabia, Pande, Amit, Singh, Manvendra, Huang, Zhi, Hallett, Eve, Xie, Yiran, Gellhaus, Alexandra, Herse, Florian, Nonn, Olivia, Gauster, Martin, Raskó, Tamás, Selbach, Matthias, Verlohren, Stefan, Staff, Anne Cathrine, Dechend, Ralf, Pecks, Ulrich, Blois, Sandra M., Hurst, Laurence D., Izsvák, Zsuzsanna   +18 more
openalex   +1 more source

Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi. [PDF]

Sci Rep
Gonzalez E, Anderson MAE, Ang JXD, Nevard K, Shackleford L, Larrosa-Godall M, Leftwich PT, Alphey L.   +7 more
europepmc   +1 more source

Additional file 5 of ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia

Anwar, Rabia, Pande, Amit, Singh, Manvendra, Huang, Zhi, Hallett, Eve, Xie, Yiran, Gellhaus, Alexandra, Herse, Florian, Nonn, Olivia, Gauster, Martin, Raskó, Tamás, Selbach, Matthias, Verlohren, Stefan, Staff, Anne Cathrine, Dechend, Ralf, Pecks, Ulrich, Blois, Sandra M., Hurst, Laurence D., Izsvák, Zsuzsanna   +18 more
openalex   +1 more source