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Regulatory elements and expression profiles
Current Opinion in Structural Biology, 1999There has been steady progress in the computational analysis of transcription control regions, but current methods of predicting the gene regulatory features of noncoding sequences are still not accurate enough to be useful in automatic genome annotation. Therefore, detailed information on the expression patterns of newly sequenced genes is more likely
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Applied bioinformatics for the identification of regulatory elements [PDF]
Nature Reviews Genetics, 2004 The compilation of multiple metazoan genome sequences and the deluge of large-scale expression data have combined to motivate the maturation of bioinformatics methods for the analysis of sequences that regulate gene transcription. Historically, these bioinformatics methods have been plagued by poor predictive specificity, but new bioinformatics ...
Albin Sandelin, Wyeth W. Wasserman
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QUERYING A DATABASE OF REGULATORY ELEMENTS
Advances in Bioinformatics and Its Applications, 2005In this paper, we present a new approach that will facilitate the process of drawing meaningful conclusions that are likely to be useful to a biologist who may be interested in only a specific functional aspect of the organism (rather than the entire genome).
Giri Narasimhan +3 more
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2012
While the annotation and functional characterization of the 2% of our genome that encodes for protein has been extremely successful, the remaining 98% still remains primarily uncharted territory. Within this territory reside gene regulatory sequences that instruct genes when, where, and at what levels to turn on or off.
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While the annotation and functional characterization of the 2% of our genome that encodes for protein has been extremely successful, the remaining 98% still remains primarily uncharted territory. Within this territory reside gene regulatory sequences that instruct genes when, where, and at what levels to turn on or off.
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Characterizing cis-regulatory elements using single-cell epigenomics
Nature reviews genetics, 2022Sebastian Preissl, K. Gaulton, B. Ren
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Genomics of Long-Range Regulatory Elements
Annual Review of Genomics and Human Genetics, 2010Transcriptional regulation of gene expression plays a significant role in establishing the diversity of human cell types and biological functions from a common set of genes. The components of regulatory control in the human genome include cis-acting elements that act across immense genomic distances to influence the spatial and temporal distribution ...
James P. Noonan, Andrew S. McCallion
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Unravelling the world of cis-regulatory elements
Medical & Biological Engineering & Computing, 2007Genome-wide comparisons indicate that only studying the coding regions will not be enough for explaining the biological complexity of an organism, while the genetic variants and the epigenetic differences of cis-regulatory elements are crucial to elucidate many complicated biological phenomena. Their various regulatory functions also play indispensable
Chih-Chuan Liang +3 more
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DNA regulatory elements for steroid hormones
Journal of Steroid Biochemistry, 1989Gene regulation by steroid hormones is mediated through an interaction of the hormone receptors with DNA regulatory sequences called hormone regulatory or responsive elements (HRE). An analysis of the HRE's in the DNA of mouse mammary tumour provirus, human metallothionein IIA gene, chicken lysozyme gene, chicken and Xenopus vitellogenin genes, growth ...
Emily P. Slater +3 more
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Computational analysis of composite regulatory elements
Mammalian Genome, 2002Combinatorial regulation is a powerful mechanism for generating specificity in gene expression, and it is thought to play a pivotal role in the formation of the complex gene regulatory networks found in higher eukaryotes. The term "Composite Element" (CE) refers to a minimal functional unit where protein-DNA and protein-protein interactions contribute ...
Jonathan R. Greene +4 more
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Regulatory crosstalk at composite response elements
Trends in Biochemical Sciences, 1991Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements. This level of communication has two striking consequences: ubiquitous factors can effect cell specificity, and closely related factors from a given family can produce very different regulatory patterns.
Keith R. Yamamoto, Jeffrey N. Miner
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