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Regulatory elements in the KlHEM1 promoter
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2008In Kluyveromyces lactis the gene encoding 5-aminolevulinate synthase, KlHEM1, is regulated at the transcriptional level by carbon source and oxygen availability. The KlHEM1 promoter, fused to the reporter lacZ gene, has been analysed by deletion and direct mutagenesis techniques in order to find regulatory elements functionally relevant in this ...
Laura, Núñez +2 more
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Genomics of Long-Range Regulatory Elements
Annual Review of Genomics and Human Genetics, 2010Transcriptional regulation of gene expression plays a significant role in establishing the diversity of human cell types and biological functions from a common set of genes. The components of regulatory control in the human genome include cis-acting elements that act across immense genomic distances to influence the spatial and temporal distribution ...
James P, Noonan, Andrew S, McCallion
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Papillomavirus 3' UTR regulatory elements
Frontiers in Bioscience, 2008Papillomaviruses infect epithelial cells causing mainly benign lesions or warts. In some rare instances, these may progress to malignancy. For example, human papillomavirus type 16 (HPV16) is the causative agent of 60 percent of cases of cervical cancer. The replication cycle of papillomaviruses is intimately linked to epithelial differentiation.
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DNA regulatory elements for steroid hormones
Journal of Steroid Biochemistry, 1989Gene regulation by steroid hormones is mediated through an interaction of the hormone receptors with DNA regulatory sequences called hormone regulatory or responsive elements (HRE). An analysis of the HRE's in the DNA of mouse mammary tumour provirus, human metallothionein IIA gene, chicken lysozyme gene, chicken and Xenopus vitellogenin genes, growth ...
M, Beato +3 more
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Prediction of Regulatory Elements
2008Finding the regulatory mechanisms responsible for gene expression remains one of the most important challenges for biomedical research. A major focus in cellular biology is to find functional transcription factor binding sites (TFBS) responsible for the regulation of a downstream gene.
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Regulatory elements and expression profiles
Current Opinion in Structural Biology, 1999There has been steady progress in the computational analysis of transcription control regions, but current methods of predicting the gene regulatory features of noncoding sequences are still not accurate enough to be useful in automatic genome annotation. Therefore, detailed information on the expression patterns of newly sequenced genes is more likely
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Computational analysis of composite regulatory elements
Mammalian Genome, 2002Combinatorial regulation is a powerful mechanism for generating specificity in gene expression, and it is thought to play a pivotal role in the formation of the complex gene regulatory networks found in higher eukaryotes. The term "Composite Element" (CE) refers to a minimal functional unit where protein-DNA and protein-protein interactions contribute ...
Ping, Qiu +4 more
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Regulatory crosstalk at composite response elements
Trends in Biochemical Sciences, 1991Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements. This level of communication has two striking consequences: ubiquitous factors can effect cell specificity, and closely related factors from a given family can produce very different regulatory patterns.
J N, Miner, K R, Yamamoto
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2012
While the annotation and functional characterization of the 2% of our genome that encodes for protein has been extremely successful, the remaining 98% still remains primarily uncharted territory. Within this territory reside gene regulatory sequences that instruct genes when, where, and at what levels to turn on or off.
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While the annotation and functional characterization of the 2% of our genome that encodes for protein has been extremely successful, the remaining 98% still remains primarily uncharted territory. Within this territory reside gene regulatory sequences that instruct genes when, where, and at what levels to turn on or off.
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TREP_DB: Transcriptional regulatory elements pattern database
Biochemical and Biophysical Research Communications, 2010Predicting and assigning functions for putative genes and hypothetical proteins are important goals in the post-genomic era. Many methods have been developed for this challenge, among which the straightforward way is function prediction using sequence homology.
Hyoung-Sam, Heo +4 more
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