Results 231 to 240 of about 867,676 (291)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Best Practices and Gaps in Current Regulatory and Health Technology Assessment Real-World Evidence Policies for Medicines and Medical Devices: Current State of Play and Next Steps. [PDF]

Clin Transl Sci
Cresswell K, Claire R, Issa L, Kubehl L, Bilal O, Purcell R, Clemente A, Wested J, Jensen LG, Sasane M, Peeters R, Shinkins B, Colvin H.   +12 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Leveraging Artificial Intelligence in Drug and Biological Product Development: An FDA and Clinical Trial Transformation Initiative Workshop Report. [PDF]

NEJM AI
Poddar A, Samson M, Innes GK, Liu Q, Saha A, Hanger M, Franzetti K, ElZarrad MK, Fakhouri TH.   +8 more
europepmc   +1 more source

From resources to efficacy over time: a longitudinal study of psychological capital, emotion regulation, and teacher self-efficacy. [PDF]

Front Psychol
Zhang P, Zhang H.
europepmc   +1 more source

A validated framework for responsible AI in healthcare autonomous systems. [PDF]

Sci Rep
Alelyani T.
europepmc   +1 more source

DANSE: a pipeline for dynamic modelling of time-series multi-omics data. [PDF]

BMC Bioinformatics
Jansen Klomp LF, Yan X, Snabel RR, Veenstra GJC, Meijer HGE, Post JN.   +5 more
europepmc   +1 more source

Editorial: Advancement of RWD/RWE utilization for enhancing drug development and benefit/risk assessment. [PDF]

Front Pharmacol
Uyama Y, Bérard A, Chan KA.
europepmc   +1 more source