Results 81 to 90 of about 595,282 (257)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

When Stock Disappears, Psychology Appears: The Moderating Effect of the Regulatory Focus on Consumer Reactions to Out-of-Stock

BAR: Brazilian Administration Review
Objective: this study investigates the moderating effect of consumers’ regulatory focus (promotion vs. prevention) on their reactions to out-of-stock (OOS) situations in retail environments.
Evandro Luiz Lopes, Eduardo Mesquita, Eliane Herrero   +2 more
doaj   +1 more source

Promotion and prevention regulatory focus LIWC dictionary. Polish adaptation and validation. [PDF]

PLoS One, 2023
Marszałek M, Miązek A, Roczniewska M.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulatory Fit and Regulatory Mode Fit in Marketing Research:

Maketingu Janaru
This study identifies current research trends and proposes future directions through a systematic review of the marketing literature on regulatory fit theory from 2015 to 2025.
Hisaaki Watanabe, Ryota Suga
doaj   +1 more source

Prevent2Protect Project: Regulatory Focus Differences in Sexual Health Knowledge and Practices. [PDF]

Arch Sex Behav, 2023
Rodrigues DL, de Visser RO, Lopes D, Prada M, Garrido MV, Balzarini RN.   +5 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Validating the Parenting Regulatory Focus Scale

Psychological Test Adaptation and Development
: Understanding the motivations and value systems behind parenting behaviors is critical for advancing family science and supporting effective, culturally sensitive interventions.
Xiang Zhou, Richard M. Lee
doaj   +1 more source