Results 171 to 180 of about 1,518,123 (337)

A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.

J Exp Biol, 2023
Farfán-Pira KJ, Martínez-Cuevas TI, Evans TA, Nahmad M.   +3 more
europepmc   +1 more source

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences [PDF]

, 2016
Matthias Drosten, Lucía Simón-Carrasco, Isabel Hernández-Porras, Carmen G. Lechuga, Maria Blasco, Harrys K.C. Jacob, Salvatore Fabbiano, Nicoletta Potenza, Xosé R. Bustelo, Carmen Guerra, Mariano Barbacid   +10 more
openalex   +1 more source

Polymorphism in regulatory gene sequences.

Genome biology, 2001
The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more important than has been suspected, and provides a lead to new therapeutic strategies.
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Characterization of regulatory sequences in alternative promoters of hypermethylated genes associated with tumor resistance to cisplatin

, 2014
Mohammed A. I. Al-Obaide, Abdel‐Salam G. Abdel‐Salam, Hytham Alobydi, Kakil Ibrahim Rasul, Ruiwen Zhang, Kalkunte S. Srivenugopal   +5 more
openalex   +2 more sources

Identification of Regulatory Sequences and Binding Proteins in the Type II Sodium/Phosphate Cotransporter NPT2 Gene Responsive to Dietary Phosphate [PDF]

, 1999
Shinsuke Kido, Ken‐ichi Miyamoto, Hiroyuki Mizobuchi, Yutaka Taketani, Ichiro Ohkido, Nobuo Ogawa, Yoshinobu Kaneko, Satoshi Harashima, Eiji Takeda   +8 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Regulatory DNA sequence Design with Reinforcement Learning [PDF]

Yang Zhao, Bing Su, Chuanbao Cao, Ji–Rong Wen   +3 more
openalex   +1 more source

A transcriptional regulatory element in the coding sequence of the human Bcl‐2 gene [PDF]

, 2004
Georgina Lang, Wendy M. Gombert, Hannah J. Gould   +2 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source