Results 181 to 190 of about 2,996,073 (354)
A "Function-First" Approach to Identify Regulatory T cell-Targeting Antibodies for Immunotherapy. [PDF]
Cancer Immunol ResCleary KLS, Semmrich M, Martensson L, Tornberg UC, Ermert D, Taylor MC, Oldham RJ, Dadas O, Buckingham JF, Kim J, Chan HTC, Palm A, Fischer AH, Boden M, Mattsson J, Holmkvist P, Lim SH, Beers SA, Frendeus B, Teige I, Cragg MS. +20 moreeuropepmc +1 more sourceCDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceSupplementary Figure 3 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Francisco Expósito, Miriam Redrado, Maeva Houry, Katherine Hastings, Magdalena Molero-Abraham, Teresa Lozano, José Luis Solórzano, Julian Sanz-Ortega, Vera Adradas, Ramon Amat, Esther Redín, Sergio León, Naroa Legarra, Javier Garcia, Diego Serrano, Karmele Valencia, Camila Robles-Oteíza, Giorgia Foggetti, Nerea Otegui, Enriqueta Felip, Juan José Lasarte, Luis Paz‐Ares, Jon Zugazagoitia, Katerina Politi, Luis M. Montuenga, Alfonso Calvo +25 moreopenalex +1 more sourceCD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
, 2004 Audrey Kinter, Margaret Hennessey, Alicia Bell, Sarah Kern, Lin Yin, Marybeth Daucher, Maria Planta, Mary McGlaughlin, Robert W. Jackson, Steven F. Ziegler, Anthony S. Fauci +10 moreopenalex +1 more sourceIL-8 in bone marrow and peripheral blood of patients with B-cell acute lymphoblastic leukemia is associated with high regulatory T cell counts, degree of tumor infiltration and expression of CXCR1 in blasts
, 2023 Diana Anaya, Sandra Paola Santander González, Natalia Murillo, Ricardo Ballesteros-Ramírez, Iliana De los Reyes, María Victoria Herrera, Julio Solano, Susana Fiorentino, Sandra Quijano +8 moreopenalex +1 more source
