Results 161 to 170 of about 1,279,789 (265)

CD8⁺ effector memory and regulatory T cell dynamics predict subclinical atherosclerotic plaque formation in healthy aging. [PDF]

Immun Ageing
Weyh C, Größer V, Minuzzi LG, Frech T, Gebhardt K, Nolte S, Dombrowski TR, Böttrich T, Hoffmann MA, Sommer N, Ringseis R, Eder K, Sossalla S, Bauer P, Krüger K.   +14 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Antigen-specific type 1 regulatory T cell responses shape immunity and disease tolerance in human malaria. [PDF]

J Clin Invest
Brockmann L.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Beyond FoxP3-Identification of a Chicken Regulatory T Cell Signature. [PDF]

Eur J Immunol
Naumann I, Ricemeyer ES, Elleder D, Plachy J, von La Roche D, Vučinić K, Göbel TW, Kaspers B, Früh SP, Härtle S.   +9 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

T Regulatory Cells and Migration

American Journal of Transplantation, 2006
D, Chen, J S, Bromberg
openaire   +2 more sources

Everolimus-based immunosuppression induces alloreactive regulatory T cell expansion combined with loss of alloreactive effector T cells. [PDF]

Front Immunol
Litjens NHR, Jonker J, Klepper M, Prevoo F, Hesselink DA, Bemelman FJ, Nurmohamed SA, Van Zuilen AD, Berger SP, Sanders JF, Betjes MGH.   +10 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Regulatory T cell approaches for graft-versus-host disease prevention. [PDF]

Curr Opin Immunol
Bader CS, Meyer EH, Negrin RS.
europepmc   +1 more source