Results 181 to 190 of about 1,257,811 (269)

Regulatory T cell memory: implications for malaria. [PDF]

J Immunol
Charles-Chess NAE, Kurup SP.
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Author Correction: Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. [PDF]

Nat Immunol
Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Zúñiga-Pflücker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL.   +15 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Regulatory T cell therapies: from patient data to biological insights. [PDF]

Front Immunol
Rodrigues KB, Eggenhuizen PJ, Bacchetta R, Good Z.   +3 more
europepmc   +1 more source

T-regulatory cell modulation: the future of cancer immunotherapy?

, 2009
Kumar, D, Dalgleish, A, Galustian, C, M Bodman-Smith, D Kumar, A Dalgleish, Nizar, S, J Copier, Meyer, B, Copier, J, Bodman-Smith, M, B Meyer, C Galustian, S Nizar   +13 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function. [PDF]

Eur J Immunol
Lee YS, Shirkey MW, Saxena V, Kong D, Ma B, Abdi R, Bromberg JS.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Taming autoimmunity: Alpha-1 antitrypsin overexpressing mesenchymal stromal cells promote regulatory T cell crosstalk to reverse diabetes. [PDF]

Mol Ther
Wei H, Gou W, Kim J, Subramanian S, Yeung T, Chakraborty P, Lotfy A, Mehrotra S, Berto S, Strange C, Wang H.   +10 more
europepmc   +1 more source