Results 1 to 10 of about 14,325,085 (286)

The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses

Cell Reports
Summary: Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in ...
Chenfei He, Shan Wang, Marion Moreews, Shengduo Pei, Guangchun Chen, Quan-Zhen Li, Alberto Del Monte Monge, Almudena R. Ramiro, Curtis Cai, Mauro Gaya, Patricia Barral, Marcus Buggert, Facundo D. Batista, Mikael C.I. Karlsson   +13 more
doaj   +2 more sources

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Frontiers in Immunology, 2020
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in
Diane G. Carnathan, Diane G. Carnathan, Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Ali H. Ellebedy, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Matthias G. Pauthner, Gabriel Ozorowski, Gabriel Ozorowski, Rafi Ahmed, Rafi Ahmed, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Andrew B. Ward, Andrew B. Ward, Guido Silvestri, Guido Silvestri, Guido Silvestri, Shane Crotty, Shane Crotty, Shane Crotty, Michela Locci, Michela Locci, Michela Locci   +31 more
doaj   +1 more source

Angioimmunoblastic T-Cell Lymphoma: A Questionable Association with Follicular Dendritic Cell Sarcoma

Case Reports in Hematology, 2017
An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture.
Daniel Benharroch, Miriam Zekzer, Karen Nalbandyan   +2 more
doaj   +1 more source

Follicular helper T cells in immune homeostasis [PDF]

Cellular & Molecular Immunology, 2012
In recent years, follicular helper T (TFH) cells have become a hot topic for immunologists due to their pivotal role in modulating antibody-mediated immune responses. Although helper T (TH) 2 cells have long been known to provide help for B-cell responses, TFH cells have been identified only recently as a distinct lineage of TH cells that is specific ...
openaire   +2 more sources

Priming of T follicular helper cells by dendritic cells [PDF]

Immunology & Cell Biology, 2013
T follicular helper cells (Tfh) are required to generate long‐lived antibody responses, which confer long‐term protection to pathogens following vaccination or infection. Despite significant advances in the field, however, little is known about the early steps that drive Tfh cell differentiation.
André, Ballesteros-Tato, Troy D, Randall   +1 more
openaire   +2 more sources

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

eLife, 2014
The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation.
Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espéli, Kenneth GC Smith   +10 more
doaj   +1 more source

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation

Frontiers in Immunology, 2019
CD4+ T helper cells are capable of differentiating into a number of effector subsets that perform diverse functions during adaptive immune responses.
Michael D. Powell, Michael D. Powell, Kaitlin A. Read, Kaitlin A. Read, Bharath K. Sreekumar, Bharath K. Sreekumar, Kenneth J. Oestreich, Kenneth J. Oestreich, Kenneth J. Oestreich   +8 more
doaj   +1 more source

Regulation of T follicular helper cells by ICOS

Oncotarget, 2015
T follicular helper (TFH) cells are gatekeepers of the humoral immune response. Without help from this CD4+ T cell subset, B cells cannot differentiate into high-affinity memory B cells and antibody-producing long-lived plasma cells which are the basis of protective immune responses.
openaire   +2 more sources

CD4+T Cells: Differentiation and Functions

Clinical and Developmental Immunology, 2012
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the ...
Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia   +3 more
doaj   +1 more source

Regulatory T cell-mediated control of chronic inflammation

Frontiers in Immunology, 2012
Autoimmune inflammation including autoantibody-mediated inflammation is responsible for the lethal organ damage that occurs during autoimmune diseases.
Keishi eFujio, Tomohisa eOkamura, Shuji eSumitomo, Kazuhiko eYamamoto   +3 more
doaj   +1 more source