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Human follicular helper T lymphocytes critical players in antibody responses
Einstein (São Paulo), 2021 Follicular helper T lymphocytes are a subpopulation of CD4+ T lymphocytes initially identified in germinal centers of follicles found in secondary lymphoid organs. The primary function of follicular helper T lymphocytes is to help B lymphocytes’ antibody
Giovana Toledo Alonso +2 more
doaj +2 more sources
T follicular helper cells in cancer
Trends in Cancer, 2023 T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated immune responses. Although the crucial function of these CD4+ T cells in infection and vaccination is well established, their involvement in cancer is only beginning to emerge.
Nicolás Gutiérrez-Melo +1 more
openaire +2 more sources
T Follicular Helper Cells in Transplantation [PDF]
Transplantation, 2016 The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21.
Giles Desmond, Walters +1 more
openaire +4 more sources
The dysfunction of T follicular helper cells [PDF]
Current Opinion in HIV and AIDS, 2014 T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody ...
Cubas R, Perreau M
openaire +3 more sources
Frontiers in Immunology, 2023 T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues.
Julien Subburayalu +2 more
doaj +1 more source
Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation. [PDF]
J Exp Med, 2020 Long X +14 more
europepmc +2 more sources
TFH cells in systemic sclerosis
Journal of Translational Medicine, 2021 Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflammatory cells in affected tissues and the ...
Pauline Beurier +8 more
doaj +1 more source
Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
doaj +1 more source
T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
openaire +2 more sources
Multi-Source Pathways of T Follicular Helper Cell Differentiation
Frontiers in Immunology, 2021 T follicular helper (Tfh) cells participate in humoral immune by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation autoantibodies.
Xiaoxue Ma +5 more
doaj +1 more source