Results 11 to 20 of about 14,325,085 (286)
Annual Review of Immunology, 2016 Although T cell help for B cells was described several decades ago, it was the identification of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of their dependence on BCL6 that led to the recognition of Tfh cells as an independent helper subset and accelerated the pace of discovery. More than 20 transcription factors,
Michelle Linterman, Vinuesa Cg, Di Yu
exaly +7 more sources
Hemato, 2022 Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi +2 more
doaj +2 more sources
Blood Relatives of Follicular Helper T Cells [PDF]
Immunity, 2011 Expression of the chemokine receptor CXCR5 identifies B follicular helper T cells. In this issue of Immunity, Morita et al. (2011) describe a heterogeneous circulating CXCR5(+)CD4(+) B cell helper population overrepresented in juvenile dermatomyositis patients.
Garcia De Vinuesa, Maria Carola +1 more
core +6 more sources
Follicular helper T cell in immunity and autoimmunity [PDF]
Brazilian Journal of Medical and Biological Research, 2016 The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh)
D. Mesquita Jr +6 more
doaj +6 more sources
T follicular helper cell diversity and plasticity [PDF]
Trends in Immunology, 2013 CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers
Pamela Schwartzberg, Jennifer L Cannons
exaly +3 more sources
Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas [PDF]
Experimental Hematology & Oncology, 2021 Background The 2016 World Health Organization (WHO) classification introduced nodal lymphomas of T follicular helper (Tfh) cell origin, such as angioimmunoblastic T-cell lymphoma (AITL), follicular peripheral T-cell lymphoma (F-PTCL), and nodal ...
Sang Eun Yoon +6 more
doaj +2 more sources
Frontiers in Immunology, 2020 The production of antibody-secreting plasma cells and memory B cells requires the interaction of T follicular helper (Tfh) cells with B cells in the follicle and is modulated by T follicular regulatory (Tfr) cells.
Maria Lopez-Ocasio +4 more
doaj +3 more sources
TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization [PDF]
Haematologica, 2015 T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy +4 more
doaj +2 more sources
Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells [PDF]
, 2015 This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonThe Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system.
Ogbe, Ane Theodora
core +7 more sources
T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]
, 2012 Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F. +5 more
core +4 more sources