Results 141 to 150 of about 1,257,811 (269)

Correlation of IL-10 with CD4^+CD25^+ T Regulatory Cells Acting on Effector T Cells

, 2006
P(論文)Regulatory T (Treg) cells can suppress effector T cells, but the mechanism underlying its suppression function is not comprehended. Here we examine the inhibiting co-stimulating molecule CTLA4 and cytokines secreted by Treg cells, and explore the ...
呉, 軍, 季, 星花, 黄, 輝, FENG, Ninghan, 馮, 寧翰, HUANG, Hui, 鄭, 峻松, 呉, 宏飛, WU, Jun, ZHENG, Junsong, WU, Hongfei, 顧, 寿智, GU, Shouzhi, LI, Xinghua, 〓, 均, DENG, Jun   +15 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Regulatory T Cell-Related Gene Polymorphisms are Associated with Risk of Lung Cancer in Patients with COPD. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhang X, Chen F.
europepmc   +1 more source

Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence

, 2009
*Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stable and functional regulatory T cell attenuates fibrotic remodeling in heart failure. [PDF]

Regen Ther
Taguchi T, Kawamura T, Mikami N, Torigata K, Harada A, Fujimura L, Ito E, Takeda M, Miki K, Sakaguchi S, Miyagawa S.   +10 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A stage-based framework to interpret regulatory T cell biology after heart transplantation. [PDF]

Front Cardiovasc Med
Wang Y, Ni M, Zheng A, Peng Y, Liu J, Xiong Q, Wang X, Savkovic V, Kang S.   +8 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Opposing functions of distinct regulatory T cell subsets in colorectal cancer. [PDF]

Immunity
Huang X, Feng D, Mitra S, Andretta ES, Hooshdaran NB, Ghelani AP, Wang EY, Frost JN, Lawless VR, Vancheswaran A, Jiang Q, Mai C, Ganesh K, Leslie CS, Rudensky AY.   +14 more
europepmc   +1 more source