Results 111 to 120 of about 130,517 (289)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

2010 Undergraduate Research Conference: Celebrating Academic Diversity Program [PDF]

, 2010
Event Program for the 2010 Undergraduate Research Conference (URC) at ...
Honors, School of
core   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

Dietary supplement use in high-intensity functional training (HIFT) athletes by competition level

Journal of the International Society of Sports Nutrition
Background Dietary supplements (DS) are used by athletes to aid sport-specific performance and recovery. High Intensity Functional Training (HIFT) is a unique sport with muscular strength/power/endurance, aerobic endurance, and rehydration concerns ...
Jack Livingston, Sofea Smith, Kworweinski Lafontant, Claudia Gonzalez, Michelle Da Silva Barbera, Linh Nguyen, Susan Kampiyil, Jeffrey R. Stout, David H. Fukuda   +8 more
doaj   +1 more source

Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults.

, 2007
Vietnam currently produces an orally administered, bivalent (O1 and O139) killed whole-cell vaccine and is the only country in the world with endemic cholera to use an oral cholera vaccine in public health practice.
Anh, Dang Duc, Attridge, Stephen, Canh, Do Gia, Carbis, Rodney, Clemens, John, Deen, Jacqueline, Han, Seung Hyun, Holmgren, Jan, Long, Phan Thi, Lopez, Anna Lena, Shin, Seong Hye, Son, Nguyen Hong, Thiem, Vu Dinh, von Seidlein, Lorenz   +13 more
core   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Drying and Rehydration of Sullius luteus Under Different Pretreatments: Kinetic Modeling, Rehydration, and Chromatic Changes

Applied Sciences
Edible mushrooms (Suillus luteus) represent valuable sources of nutrients and bioactive compounds that are sensitive to drying conditions. The objective of this study was to determine the drying time, kinetic model, effective diffusivity, activation ...
Alfredo Fernandez-Ayma, Víctor Justiniano Huamaní-Meléndez, Luis Fernando Pérez-Falcón, Franklin Lozano, Guadalupe Chaquilla-Quilca   +4 more
doaj   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

REHYDRATION OF AIR-DRIED CERVICAL SMEARS: AN ALTERNATIVE TO ROUTINE WET FIXATION

Acta Medica Iranica, 2007
To prepare Pap smears, the routine practice is to fix the slides immediately in 95% ethanol. This study was performed to evaluate the possibility of routine use of alternative method of air-drying and rehydration prior to alcohol fixation instead of ...
A. Zare-Mirzaie, K. Khalili-Alam M. Abolhasani   +1 more
doaj