Results 101 to 110 of about 603,909 (294)
Applied SciencesPrevious studies of train-induced tunnel responses have mainly focused on completed tunnels or symmetric loading conditions, while the dynamic behavior of unfinished double-arch tunnels subjected to unilateral train loading through temporary trestles ...
Gaole Zhang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Urban LifelineBuried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li +5 more
doaj +1 more source
Frontiers in Marine ScienceIntroductionUsing May–November 2022 CTD observations from the central–eastern southern coastal waters of Korea, we quantified the variability of oceanic fronts and their coupling with water-column stability.MethodsWe used conventional |∇T|, |∇S ...
Baekjin Kim +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Remote SensingTemporal alterations in coastlines depict the significant changes in coastal areas, driven by both natural processes and human activities. For island nations, monitoring of the coastline is essential due to their vulnerability to such impacts.
Sree Juwel Kumar Chowdhury, Chan-Su Yang
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source