Results 81 to 90 of about 603,909 (294)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1994 SUMMARY Reinforcement is here meant the addition of plots of standard treatments to the blocks of a non-orthogonal design to improve it. The purpose could be either to aid a comparison of the existing treatments or to facilitate their comparison with the standards.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Marine Science and EngineeringUnderwater gliders are suited for long-duration oceanographic observation, but their endurance is bounded by onboard energy capacity. An overlooked source of energy loss is the attitude control system, which repeatedly repositions the internal moving ...
Sung-Hyub Ko +5 more
doaj +1 more source
REINFORCEMENT OF INHIBITION [PDF]
Journal of the Experimental Analysis of Behavior, 1983 A differential‐reinforcement‐of‐other‐behavior (DRO) schedule with trials and delayed reinforcement was investigated. Periodically a wheel was briefly available to rats, followed six seconds later by brief availability of a bar. Variable‐ratio food reinforcement of wheel turns was adjusted to give 95% turns.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SensorsFish species’ biological vocalizations serve as essential acoustic signatures for passive acoustic monitoring (PAM) and ecological assessments. However, limited availability of high-quality acoustic recordings, particularly for region-specific species ...
Sunhyo Kim +7 more
doaj +1 more source
The effects of delay-to-reinforcement, response requirement and schedule duration on performance under fixed-ratio schedules [PDF]
, 2011 Experiment 1 examined the effects of delay-to-reinforcement on between-ratio pausing in multiple fixed-ratio 5 fixed-ratio 5 schedules. In one component the reinforcer was delivered immediately on completion of the ratio, and in the other there was a ...
Harris, Aimee Rebecca
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source