Results 81 to 90 of about 1,160,351 (242)

Comfort or hesitancy: A cross-sectional study of modifiable factors associated with co-vaccination behavior among United States and Canadian adults

Preventive Medicine Reports
Objective: Co-vaccination, or receiving multiple vaccines at once, may improve vaccination uptake and reduce missed opportunities to vaccinate. Although generally considered safe and effective, co-vaccination is not well accepted outside of travel and ...
Emily Frith, Sarah Deedat, E. Susanne Blazek, Amy Bucher   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Seasonal frontal variability and stratification coupling from 2022 CTD observations in the southern coastal waters of Korea

Frontiers in Marine Science
IntroductionUsing May–November 2022 CTD observations from the central–eastern southern coastal waters of Korea, we quantified the variability of oceanic fronts and their coupling with water-column stability.MethodsWe used conventional |∇T|, |∇S ...
Baekjin Kim, Seonghyeon Kim, Soonyeol Kwon, Sunjong Lee, Eung Kim   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Influence of crossing fault position and site soil on the mechanical properties of bellows joint connected buried pipelines under direct shear

Urban Lifeline
Buried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li, Guoxing Lu, Yang Lv, Xue-jie Zhang, Guo-bo Wang, Bo Zhong   +5 more
doaj   +1 more source

A Study on the Coastline Extraction and Coastal Change Analysis Using Sentinel-2 Imagery in Funafuti, Tuvalu

Remote Sensing
Temporal alterations in coastlines depict the significant changes in coastal areas, driven by both natural processes and human activities. For island nations, monitoring of the coastline is essential due to their vulnerability to such impacts.
Sree Juwel Kumar Chowdhury, Chan-Su Yang
doaj   +1 more source

An experimental investigation of retro-reinforced clay brick arches

, 2010
This paper describes the laboratory testing of eight 2.95m span segmental profile clay brick arches. Seven of the arches were strengthened with longitudinal intrados (soffit) reinforcement; the eighth was left unreinforced as an experimental control ...
Ashour, AF, Chen, Y, Garrity, SW
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Reactive Reinforcement Learning in Asynchronous Environments

Frontiers in Robotics and AI, 2018
The relationship between a reinforcement learning (RL) agent and an asynchronous environment is often ignored. Frequently used models of the interaction between an agent and its environment, such as Markov Decision Processes (MDP) or Semi-Markov Decision
Jaden B. Travnik, Jaden B. Travnik, Kory W. Mathewson, Kory W. Mathewson, Richard S. Sutton, Patrick M. Pilarski, Patrick M. Pilarski   +6 more
doaj   +1 more source