Results 61 to 70 of about 245,513 (267)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Reconstruction Modeling and Validation of Brown Croaker (Miichthys miiuy) Vocalizations Using Wavelet-Based Inversion and Deep Learning

Sensors
Fish species’ biological vocalizations serve as essential acoustic signatures for passive acoustic monitoring (PAM) and ecological assessments. However, limited availability of high-quality acoustic recordings, particularly for region-specific species ...
Sunhyo Kim, Jongwook Choi, Bum-Kyu Kim, Hansoo Kim, Donhyug Kang, Jee Woong Choi, Young Geul Yoon, Sungho Cho   +7 more
doaj   +1 more source

REINFORCEMENT OF INHIBITION [PDF]

Journal of the Experimental Analysis of Behavior, 1983
A differential‐reinforcement‐of‐other‐behavior (DRO) schedule with trials and delayed reinforcement was investigated. Periodically a wheel was briefly available to rats, followed six seconds later by brief availability of a bar. Variable‐ratio food reinforcement of wheel turns was adjusted to give 95% turns.
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Study on the Detection of Sleeve Grouting Defects Using the Impact-Echo Method: FEM and Experimental Analysis

Applied Sciences
Grouted sleeve connections are widely employed in the substructures of prefabricated bridges. After installation, the grout filling condition inside the sleeves cannot be directly inspected, while grouting defects may significantly compromise the ...
Anfan Shang, Yunhui Li, He Zhang, Yuman Dai, Mi Zhou   +4 more
doaj   +1 more source

Reinforcement Learning

, 2020
Chapter in "A Guided Tour of Artificial Intelligence Research ...
Buffet, Olivier, Pietquin, Olivier, Weng, Paul   +2 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Energy-Efficient Pitch Control for a 1000 m-Class Underwater Glider: A Comparative Study of PID, Fuzzy, and ANFIS Controllers Based on Experimental Power Models

Journal of Marine Science and Engineering
Underwater gliders are suited for long-duration oceanographic observation, but their endurance is bounded by onboard energy capacity. An overlooked source of energy loss is the attitude control system, which repeatedly repositions the internal moving ...
Sung-Hyub Ko, Hyunjoon Cho, Daehyeong Ji, Jong-Wu Hyeon, Seom-Kyu Jung, Joon-Young Kim   +5 more
doaj   +1 more source