Results 41 to 50 of about 1,160,351 (242)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Microstructures, Mineral Compositions, and Mechanical Properties of Red-Layers in Southern China

open access: yesAdvances in Materials Science and Engineering, 2018
In order to reveal the water-induced damage mechanism and mechanical properties of red-layers in Southern China, typical red-layer samples are experimentally studied by scanning electron microscope (SEM), energy spectrum analysis, XRD, and mechanical ...
Huizhi Zhang, Jifeng Liu
doaj   +1 more source

Experimental Investigation and Numerical Simulation of Corrugated Steel Plate Shear Wall Considering the Gravity Load

open access: yesBuildings, 2023
The corrugated steel plate shear wall (CSPSW) has high strength, ductility, and energy dissipation capacity and can be used as the lateral force-resisting system of multi-story and high-rise buildings. The vertical load transmitted by the upper floor and
Fangfang Li   +4 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Study on Mechanical Properties of Steel Fiber-Reinforced Geopolymer Concrete under Multi-Axial Loads

open access: yesBuildings
Steel fiber-reinforced geopolymer concrete (SFRGPC) is an inorganic cementitious material with environmentally friendly features. As compared to conventional concrete, SFRGPC has greater strength and durability, but it is brittle, making it similar to ...
Pengtao Wu, Xuan Wan, Qun Lu, Yan Zhang
doaj   +1 more source

CityFlow: A Multi-Agent Reinforcement Learning Environment for Large Scale City Traffic Scenario

open access: yes, 2019
Traffic signal control is an emerging application scenario for reinforcement learning. Besides being as an important problem that affects people's daily life in commuting, traffic signal control poses its unique challenges for reinforcement learning in ...
Ding, Yaoyao   +9 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

How are Machine Learning and Artificial Intelligence Used in Digital Behavior Change Interventions? A Scoping Review

open access: yesMayo Clinic Proceedings: Digital Health
To assess the current real-world applications of machine learning (ML) and artificial intelligence (AI) as functionality of digital behavior change interventions (DBCIs) that influence patient or consumer health behaviors.
Amy Bucher, PhD   +2 more
doaj   +1 more source

Influence of Infill Wall Configuration on Failure Modes of RC Frames

open access: yesShock and Vibration, 2018
An improper configuration of masonry infill walls in RC frame may lead to short column effect on the columns, which is harmful to the seismic behavior of the structure.
Xiaojie Zhou   +3 more
doaj   +1 more source

Dynamic Analysis on the Parametric Resonance of the Tower–Multicable–Beam Coupled System

open access: yesApplied Sciences, 2022
Considering the effect of the bridge deck’s bending stiffness and the indirect effect of adjacent cables (CEB), this paper aims to propose a refined model to reliably analyze the complex internal resonance mechanism of the tower–multicable–beam coupled ...
Shuanhai He   +5 more
doaj   +1 more source

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