Results 71 to 80 of about 245,513 (267)
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1994 SUMMARY Reinforcement is here meant the addition of plots of standard treatments to the blocks of a non-orthogonal design to improve it. The purpose could be either to aid a comparison of the existing treatments or to facilitate their comparison with the standards.
openaire +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Preventive Medicine ReportsObjective: Co-vaccination, or receiving multiple vaccines at once, may improve vaccination uptake and reduce missed opportunities to vaccinate. Although generally considered safe and effective, co-vaccination is not well accepted outside of travel and ...
Emily Frith +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Urban LifelineBuried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li +5 more
doaj +1 more source
Remote SensingTemporal alterations in coastlines depict the significant changes in coastal areas, driven by both natural processes and human activities. For island nations, monitoring of the coastline is essential due to their vulnerability to such impacts.
Sree Juwel Kumar Chowdhury, Chan-Su Yang
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source