Results 91 to 100 of about 603,909 (294)
Nagoya Mathematical Journal, 1966 The device of representing a predicate by a universal sentence gives rise to logics of higher order. To represent an object constructed by a series of certain steps, we usually use terms. To represent a predicate constructed by a series of certain steps, we now use sentences in general.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Applied SciencesGrouted sleeve connections are widely employed in the substructures of prefabricated bridges. After installation, the grout filling condition inside the sleeves cannot be directly inspected, while grouting defects may significantly compromise the ...
Anfan Shang +4 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
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Refinement of biologically inspired models of reinforcement learning [PDF]
, 2010 Reinforcement learning occurs when organisms adapt the propensities of given behaviours on the basis of associations with reward and punishment. Currently, reinforcement learning models have been validated in minimalist environments in which only 1-2 ...
Aquili, Luca
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Preventive Medicine ReportsObjective: Co-vaccination, or receiving multiple vaccines at once, may improve vaccination uptake and reduce missed opportunities to vaccinate. Although generally considered safe and effective, co-vaccination is not well accepted outside of travel and ...
Emily Frith +3 more
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, 2020 Chapter in "A Guided Tour of Artificial Intelligence Research ...
Buffet, Olivier +2 more
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Deep Reinforcement Learning Approaches for the Game of Briscola [PDF]
, 2023 openReinforcement learning is increasingly becoming one of the most interesting areas of research in recent years. It is a machine learning approach that aims to design autonomous agents capable of learning from interaction with the envi- ronment ...
SINGH, AMANPREET
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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