Results 111 to 120 of about 1,717,828 (345)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Influence of crossing fault position and site soil on the mechanical properties of bellows joint connected buried pipelines under direct shear

open access: yesUrban Lifeline
Buried pipeline systems are vulnerable to joint damage in earthquakes. Previous studies have shown that bellows joints are effective in increasing deformation capacity and reducing the axial force of the main pipeline.
Fang-fang Li   +5 more
doaj   +1 more source

A Study on the Coastline Extraction and Coastal Change Analysis Using Sentinel-2 Imagery in Funafuti, Tuvalu

open access: yesRemote Sensing
Temporal alterations in coastlines depict the significant changes in coastal areas, driven by both natural processes and human activities. For island nations, monitoring of the coastline is essential due to their vulnerability to such impacts.
Sree Juwel Kumar Chowdhury, Chan-Su Yang
doaj   +1 more source

The contribution of 211 particles to the mechanical reinforcement mechanism of 123 superconducting single domains [PDF]

open access: green, 2003
J-P Mathieu   +7 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

On a three-dimensional lattice approach for modelling corrosion induced cracking and its influence on bond between reinforcement and concrete

open access: yes, 2010
The present work involves the discrete modelling of corrosion induced cracking and its influence on the bond between reinforcement and concrete. A lattice approach is used to describe the mechanical interaction of a corroding reinforcement bar, the ...
Davies, Trevor, Grassl, Peter
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

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