Results 61 to 70 of about 17,567 (255)

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

A Consensus Approach for Targeted Muscle Reinnervation in Amputees

, 2023
Amputations have been performed with few modifications since the dawn of surgery. Blood vessels are ligated, bones are shortened, and nerves are cut. In a percentage of people, this can result in severe neuropathic, residual limb, and phantom limb pain ...
Kyle R. Eberlin, MD, Gregory A. Dumanian, MD, Brendan J. MacKay, MD, Benjamin K. Potter, MD, Jason M. Souza, MD, Ian L. Valerio, MD, MBA, Grant M. Kleiber, MD, Margaret S. Roubaud, MD, Bryan J. Loeffler, MD, David A. Brown, MD, PhD, Jason H. Ko, MD, MBA, Stephen J. Kovach, MD, R. Glenn Gaston, MD   +12 more
core   +1 more source

Clinically Available Low Intensity Ultrasound Devices do not Promote Axonal Regeneration After Peripheral Nerve Surgery—A Preclinical Investigation of an FDA-Approved Device

Frontiers in Neurology, 2018
The slow axonal regeneration and consecutive delayed muscle reinnervation cause persistent functional deficits following peripheral nerve injury, even following sufficient surgical nerve reconstruction. Preclinically, adjunct ultrasound therapy has shown
Simeon C. Daeschler, Leila Harhaus, Konstantin D. Bergmeister, Arne Boecker, Bernd Hoener, Ulrich Kneser, Philipp Schoenle   +6 more
doaj   +1 more source

Can MRI quantify the volume changes of denervated facial muscles?

European Journal of Translational Myology, 2020
Could manual segmentation of magnetic resonance images be used to quantify the effects of transcutaneous electrostimulation and reinnervation of denervated facial muscle?
Valeria Mastryukova, Dirk Arnold, Daniel Güllmar, Orlando Guntinas-Lichius, Gerd Fabian Volk   +4 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Peripheral sensory nerve regeneration: Novel target in bone tissue engineering

Brain-X
Synthetic biomaterials are emerging candidate solutions for treating large bone defects. However, the clinical performances of most synthetic materials are not satisfactory, with the need for improvement in design and synthesis.
Lan Xiao, Jiaying Liu, Fuhua Yan, Yin Xiao   +3 more
doaj   +1 more source

Polyimide Electrode-Based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration

Frontiers in Neurology, 2019
Given the increasing use of regenerative free muscle flaps for various reconstructive procedures and neuroprosthetic applications, there is great interest and value in their enhanced regeneration, revascularization, and reinnervation for improved ...
Shriya Srinivasan, Shriya Srinivasan, Keval Vyas, Malia McAvoy, Malia McAvoy, Peter Calvaresi, Omar F. Khan, Omar F. Khan, Robert Langer, Robert Langer, Robert Langer, Robert Langer, Daniel G. Anderson, Daniel G. Anderson, Daniel G. Anderson, Daniel G. Anderson, Hugh Herr   +16 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Glycosaminoglycan-promoted muscle reinnervation and insulin-like growth factor-I levels are affected by anti-growth hormone-releasing hormone exposure

, 2001
The present study shows that exposure to antibodies to growth hormone-releasing hormone (GHRH) partially counteracted the promoting effects of treatment with glycosaminoglycans (GAGs) on muscle reinnervation.
C. Citterio, E. Muller, A. Gorio, A. Di Giulio   +3 more
core   +1 more source

Macrophage-derived vascular endothelial growth factor-A is integral to neuromuscular junction reinnervation after nerve injury [PDF]

, 2020
Functional recovery in the end target muscle is a determinant of outcome after peripheral nerve injury. The neuromuscular junction (NMJ) provides the interface between nerve and muscle and includes non-myelinating terminal Schwann cells (tSCs).
Pan, Deng, Santosa, Katherine B, Vannucci, Bianca, Snyder-Warwick, Alison K, Lu, Chuieng-Yi, Jablonka-Shariff, Albina, Turnbull, Isaiah, Fuchs, Anja, Wood, Matthew D   +8 more
core   +1 more source