Results 111 to 120 of about 48,899 (225)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

The first reintroduction project for mhorr gazelle (Nanger dama mhorr) into the wild: Knowledge and experience gained to support future conservation actions

Global Ecology and Conservation, 2019
Reintroductions continue to be an important conservation action for endangered species. Until this, all reintroduction projects for Mhorr gazelle (Nanger dama mhorr) had remained at the stage where the animals live in fenced protected areas of different ...
T. Abáigar, E. Rodríguez-Caballero, Cristina Martínez, Zouhair Amaouch, M. L. Samlali, F. Aparicio, Taufik El Balla, Abderrahim Essalhi, Jesús Fernández, Francisco García, M. Haya, A. M’Bareck, H. M'Bareck, L. González, Pablo Fernández de Larrínoa   +14 more
semanticscholar   +1 more source

Why you cannot ignore disease when you reintroduce animals

, 2016
All wild animal populations harbor a range of parasitic organisms, ranging from viruses and bacteria to multicellular parasites such as helminths and arthropods.
Muths, Erin, McCallum, Hamish
core  

Martinez et al. Ocelot Reintroduction PVA Vortex data

, 2023
In our study, we used population viability analyses to compare different ocelot reintroduction strategies for an identified reintroduction area. A to-be established ocelot breeding program providing individual ocelots for reintroduction will likely be ...
Lindsay Martinez (17327218)
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Thermal Control of Concentric Topographies Patterned by Dynamic Electro‐Templated Generated Chiral Solitonic Structures

Advanced Science, EarlyView.
An electro‐templating strategy directs the relaxation of cholesteric finger loops into discrete concentric rings whose geometry is electrically programmed. The photopolymerized structures retain the topological defect pattern and, upon heating, show reversible, castle‐like surface modulation.
Jacques A. Peixoto, Hanqing Zhao, Dirk J. Broer, Ivan I. Smalyukh, Danqing Liu   +4 more
wiley   +1 more source

Identifying Important Areas for the Release of Five Endemic Species in a Mountainous Landscape: Inference from Spatial Modeling Techniques

Jurnal Manajemen Hutan Tropika
Efforts to release animals resulting from evacuation and rehabilitation into their natural habitats are important practices in wildlife conservation. Before releasing the animals, it is important to assess the habitat suitability of the areas to support
Dede Aulia Rahman, Misbah Satria Giri, Ahmad Munawir, Jacqueline L Sunderland-Groves   +3 more
doaj   +1 more source

A method for the reintroduction of entire benthic invertebrate communities in formerly degraded streams

Limnologica, 2019
Reintroduction is a commonly used tool in wildlife conservation. Although freshwater ecosystems are among the most threatened worldwide, reintroductions of entire benthic invertebrate communities h ...
P. Haase, F. Pilotto
semanticscholar   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source