Results 81 to 90 of about 56,312 (296)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Why you cannot ignore disease when you reintroduce animals

, 2016
All wild animal populations harbor a range of parasitic organisms, ranging from viruses and bacteria to multicellular parasites such as helminths and arthropods.
Muths, Erin, McCallum, Hamish
core  

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Critical steps to ensure the successful reintroduction of the Eurasian red squirrel

, 2015
Wildlife reintroduction strategies aim to establish viable long–term populations, promote conservation awareness and provide economic benefits for local communities.
Pinto Vieira, Bianca, Rocha, R.G., Fonseca, C., Rocha, R. G., Vieira, B. P   +4 more
core  

Reintroduction and De-extinction

, 2013
In this article the author discusses de-extinction, which is a process whereby the DNA of an extinct species is used to create an organism that is either a member of the extinct species or resembles it. Topics include the moral and ethical concerns of de-
Jørgensen, Dolly,
core   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source

Identifying Important Areas for the Release of Five Endemic Species in a Mountainous Landscape: Inference from Spatial Modeling Techniques

Jurnal Manajemen Hutan Tropika
Efforts to release animals resulting from evacuation and rehabilitation into their natural habitats are important practices in wildlife conservation. Before releasing the animals, it is important to assess the habitat suitability of the areas to support
Dede Aulia Rahman, Misbah Satria Giri, Ahmad Munawir, Jacqueline L Sunderland-Groves   +3 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

Advanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li, Yongqiang Chen, Dong Ding, Xuehai Zhang, Xuxiang Jia, Zhanhui Zhang, Yafei Wang, Weihua Li, Hui Zhang, Jihua Tang   +9 more
wiley   +1 more source

Supporting reintroduction planning [PDF]

Aim Reintroducing carnivores is a widely used approach to restore the natural integrity of ecosystems. Species distribution models (SDMs) and connectivity analyses are valuable tools for planning reintroductions and identifying release sites but are ...
Biondi, Maurizio, Serva, Davide, Iannella, Mattia, Krofel, Miha, Cerasoli, Francesco   +4 more
core   +1 more source