Results 161 to 170 of about 20,124 (268)

Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries. [PDF]

Stem Cell Res Ther
Tu H, Hosaka A, Hichiwa G, Wang Y, Kazuki K, Tabata T, Osaki M, Nakayama Y, Kanazawa I, Honma K, Kimura MT, Gao X, Ogata N, Abe S, Oshimura M, Kazuki Y.   +15 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

High-Resolution Ultrasound-Guided Facial Adipose Tissue Restructuring: A Precise Approach to Rejuvenation in a Clinical Case. [PDF]

Cureus
Velazco G, Herrera A, Gutierrez Alvarez JH.   +2 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan. [PDF]

Aging Cell
Bene MR, Zhang C, Westbrook R, Gabrawy M, Marx R, Wu Y, Khadeer M, Ubaida-Mohien C, Ferrucci L, Moaddel R, Le A, Walston JD, Lee JL, Abadir PM.   +13 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others. [PDF]

Nat Commun
Moran R, Pridham G, Toledano Y, Alon U.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Balanced Restoration: Optimizing Midface Rejuvenation Using Hyaluronic Acid Fillers. [PDF]

Plast Reconstr Surg Glob Open
Rohrich RJ, Cetto R, Gallagher CJ, Weir D, Hollander DA, Brown J, Wu K.   +6 more
europepmc   +1 more source