Results 51 to 60 of about 19,097 (235)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Skin responses to fractional photothermolysis [PDF]

, 2006
Background and Objective Fractional photothermolysis (FP) is a new concept using arrays of microscopic thermal damage patterns to stimulate a therapeutic response.
Anderson, Rox, Laubach, Hans-Joachim, Tannous, Zeina   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin

Marine Drugs
Plant-derived extracellular vesicles (EVs) elicit diverse biological effects, including promoting skin health. EVs isolated from Ecklonia cava (EV-EC) carry heat shock protein 70 (HSP70), which inhibits key regulators such as TNF-α, MAPKs, and NF-κB ...
Sosorburam Batsukh, Seyeon Oh, Ji Min Lee, Judy Hong Jin Joo, Kuk Hui Son, Kyunghee Byun   +5 more
doaj   +1 more source

DEFORMATION BEHAVIOR OF NANO/MICRO REINFORCED PMMA [PDF]

, 2010
Práce sleduje vliv velikosti částic na elastický modul a deformační chování za mezí kluzu. Bylo pozorováno, že jak elastická oblast, tak oblast za mezí kluzu ukazuje silnou závislost chování na velikosti částic.
Recman, Lukáš
core  

Epigenetics in plant tissue culture [PDF]

Plants produced vegetatively in tissue culture may differ from the plants from which they have been derived. Two major classes of off-types occur: genetic ones and epigenetic ones. This review is about epigenetic aberrations.
Klerk, G.J.M., de, Smulders, M.J.M.
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigations on microstructural and mechanical properties of long-term thermally exposed superalloy Mar-M247 after rejuvenation heat treatment

Journal of Materials Research and Technology
Mar-M247 is a polycrystalline nickel-based superalloy utilized for blades in heavy-duty gas turbines. However, the microstructure degradation of the alloy during long-term aging includes coarsening of the γ′ phase and precipitation of TCP phase, which ...
Song Wu, Lexin Yang, Yubing Pei, Fenling Wang, Changshuai Wang, Chao Luo, Bin Zhou, Xiufang Gong   +7 more
doaj   +1 more source

Age, Depth, and Residual Depth Anomalies in the North Pacific: Implications for Thermal Models of the Lithosphere and Upper Mantle [PDF]

, 1986
We present an empirical basement depth versus age relation for the North Pacific Ocean, based on the statistical treatment of an ocean-wide gridded data set.
Renkin, Miriam K., Sclater, John G.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source