Results 111 to 120 of about 633,065 (305)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Social environmental factors as predictors of late relapse: prospective follow up results among Quitline users in Republic of Korea

, 2018
Background Although Quitlines have provided services for cessation with easy accessibility, convenient counseling, and high effectiveness, little attention has been paid to research on predictors of delayed relapse.
Jin-Kyoung Oh, Jin-Ju Park, E Hwa Yun, Eun-Young Park, Bo Yoon Jung, Min Kyung Lim   +5 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Exploring the process of change and acceptability of mindfulness

, 2012
Mindfulness is becoming an increasingly popular intervention for affective disorders, such as depression. Mindfulness Based Cognitive Therapy (MBCT) is evidenced as being an effective intervention for reducing depressive relapse for people with three or ...
Walton, Ruchika
core   +1 more source

Utility of a Large Series of B‐Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System

Cancer Medicine
Background In B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), chromosomal translocations are strongly associated with prognoses. RNA sequencing (RNA‐seq) is a powerful technology that reveals a close correlation between types of translocation ...
Minori Tamai, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Koshi Akahane, Kumiko Goi, Kanji Sugita, Chihiro Tomoyasu, Toshihiko Imamura, Hiroaki Goto, Takeshi Inukai   +10 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

NSE and ProGRP Are Promising Markers for Diagnosis, Efficacy Evaluation, Follow‐Up Monitoring, and Prognosis of Small Cell Esophageal Carcinoma

Thoracic Cancer
Background To investigate the clinical implications of serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and pro‐gastrin‐releasing peptide (ProGRP) in small cell esophageal carcinoma (SCEC).
Di Liu, Dan Wu, Jianjiao Ni, Junhua Zhang, Suhong Xie   +4 more
doaj   +1 more source

SPREADING PATTERN OF INFECTIOUS DISEASES: SUSCEPTIBLE INFECTED RECOVERED MODEL WITH VACCINATION AND DRUG-RESISTANT CASES (APPLICATION ON TB DATA IN INDONESIA)

Barekeng
Mycobacterium tuberculosis is the causative agent of the infectious illness tuberculosis (TB). Indonesia is the world's third-highest TB burden country. TB transmission is prevented by the BCG vaccination.
Purnami Widyaningsih, Siti Roqhilu Yumaroh, Dewi Retno Sari Saputro   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source