Results 131 to 140 of about 633,065 (305)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim of the study: evaluate the role of normalization of humoral immunity to address dose reduction or discontinuation of immunosuppressors in patients with autoimmune hepatitis (AIH).Patients and methods.
A. O. Bueverov, S. V. Koblov, P. O. Bogomolov   +2 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Factors associated with the risk of relapse in schizophrenic patients after a response to electroconvulsive therapy: a retrospective study

, 2015
Chiyo Shibasaki,1 Minoru Takebayashi,1,2 Yasutaka Fujita,1 Shigeto Yamawaki3 1Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima ...
Shibasaki C, Takebayashi M, Yamawaki S, Fujita Y   +3 more
core  

Clinical Characteristics and Risk of Relapse for Patients with Stage I–II Diffuse Large B-cell Lymphoma Treated in First Line with Immunochemotherapy

, 2013
Diffuse large b-cell lymphoma (DLBCL) is an aggressive and potentially curable lymphoma that presents itself as stage I-II in 30% of all cases. It is known that in these localized stages, 15-20% of patients treated without rituximab eventually relapse ...
V. Romagosa, A. Fernández de Sevilla, S. Mercadal, F. Climent, E. Domingo-Doménech, A. Oliveira, E. González-Barca   +6 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RETRACTED: Anti-relapse chemotherapy in liver echinococcosis

Сеченовский вестник, 2016
RETRACTED ARTICLEStudy objective – the effectiveness of clinical-based schemes of Albendazole anti-relapse chemotherapy. We studied the long-term results of surgical treatment of 709 patients with various forms of liver echinococcosis.
A. F. Chernousov, T. Y. Mukantaev, D. V. Vychuzhanin, V. V. Levkin, R. M. Nurutdinov   +4 more
doaj  

Non-adherence to medication, malaria relapse, and asymptomatic reservoirs in malaria transmission: A narrative review

Public Health of Indonesia
Background: Malaria elimination remains a pressing global health priority, yet progress is hindered by interconnected human-driven factors that sustain residual transmission.
Muhamad Sahiddin, Hasanuddin Ishak, Andi Arsunan Arsin, Anwar Mallongi, Muhammad Arsyad, Firdaus Hamid   +5 more
doaj   +1 more source

Neurophysiological correlates of response inhibition predict relapse in detoxified alcoholic patients: some preliminary evidence from event-related potentials

, 2014
Géraldine Petit, Agnieszka Cimochowska, Charles Kornreich, Catherine Hanak, Paul Verbanck, Salvatore CampanellaLaboratory of Psychological Medicine and Addictology, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB ...
Hanak C, Petit G, Verbanck P, Campanella S, Kornreich C, Cimochowska A   +5 more
core  

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source