Results 31 to 40 of about 41,565 (267)

Dimethyl fumarate for relapsing-remitting multiple sclerosis [PDF]

The Lancet Neurology, 2014
For many years the only drugs licensed for the treatment of multiple sclerosis (MS) were administered by injection (interferon beta, glatiramer and ▼natalizumab). Recently, three oral drugs have become available. We have previously reviewed the use of ▼fingolimod for highly active relapsing-remitting MS1 and ▼teriflunomide for the management of ...
Martyn J, Burke, Joanna, Richardson, Elisabeth, George, Amanda I, Adler   +3 more
openaire   +4 more sources

Faster progression to multiple sclerosis disability is linked to neuronal pathways associated with neurodegeneration: An ethnicity study.

PLoS ONE, 2023
Although the causes of multiple sclerosis are largely unknown, genetic and environmental components play an important role. Geographic distribution, varying with latitude, reflects both genetic and environmental influences.
Gil Harari, Michael Gurevich, Mark Dolev, Rina Zilkha Falb, Anat Achiron   +4 more
doaj   +1 more source

Thalamic neurodegeneration in relapsing-remitting multiple sclerosis

Neurology, 2003
To define the extent of neuronal injury and loss in thalamic gray matter in patients with relapsing-remitting (RR) MS and to characterize how these neuronal pathologic changes are related to disease duration.The authors studied 14 patients with RRMS (Expanded Disability Status Scale score, mean 3.25, range 2.0 to 6.0) and 14 (8 men, 6 women) age ...
A. CIFELLI, M. WYLEZINSKA, P. JEZZARD, J. PALACE, ALECCI, MARCELLO, P. MATTHEWS   +5 more
openaire   +5 more sources

Evidence for grey matter MTR abnormality in minimally disabled patients with early relapsing-remitting multiple sclerosis

, 2004
Objectives: To establish whether magnetisation transfer ratio (MTR) histograms are sensitive to change in normal appearing grey matter (NAGM) in early relapsing-remitting multiple sclerosis (RRMS) in the absence of significant disability; and to assess ...
Griffin, C M B, Kapoor, R., Miller, D.H., Chard, D T, Hadjiprocopis, A., Ramio-Torrenta, L, Barker, G J; id_orcid, Davies, G.R., Ramió-Torrentà, L., Griffin, C.M.B., Rashid, W., Chard, D.T., Davies, G R, Miller, D H, Rashid, W, Thompson, A.J., Kapoor, R, Thompson, A J, Barker, G.J., Hadjiprocopis, A   +19 more
core   +1 more source

Impact of treatment with dimethyl fumarate on sleep quality in patients with relapsing-remitting multiple sclerosis: A multicentre Italian wearable tracker study

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2023
Background Sleep disorders are common in patients with multiple sclerosis and have a bidirectional interplay with fatigue and depression. Objective To evaluate the effect of treatment with oral dimethyl fumarate on the quality of sleep in relapsing ...
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi ME Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli,   +14 more
doaj   +1 more source

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS [PDF]

, 2012
Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify ...
Salvetti, M, D. Brown, T. Coetzee, K. Sharrock, Lee, K, Brown, D, Feinstein, A, Thompson, A, K. Zuidwijk, D. Chandraratna, Kapoor, R, Fox, RJ, Zuidwijk, K, K. Lee, A. Thompson, G. Comi, Toosy, A, Baneke, P, Browne, P, Sharrock, K, O. Ciccarelli, P. Browne, A. Feinstein, Comi, G, R. J. Fox, Chandraratna, D, P. Zaratin, Baker, D, R. Kapoor, Ciccarelli, O, Zaratin, P, P. Baneke, Coetzee, T, D. Baker, SALVETTI, Marco, A. Toosy   +35 more
core   +1 more source

Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines [PDF]

, 2020
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS, most current diagnostic and treatment algorithms need revision and updating.
Almahdawi, Akram M., Dahdaleh, Maurice P., Alsaadi, Taoufik M., Inshasi, Jihad Said, Yamout, Bassem I., Bohlega, Saeed A., Al-Jumah, Mohammed A., Alsharoqi, Isa Ahmed, Koussa, Salam F., AlKhawajah, Mona Marwan, Al Khaburi, J., Alroughani, Raed A., Goueider, Riyad, Khoury, Samia J., Sahraian, Mohammad Ali, Daodi, S., Slassi, E., Zakaria, Magd Fouad, Hashem, Saher S.   +18 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Segmented corpus callosum diffusivity correlates with the Expanded Disability Status Scale score in the early stages of relapsing-remitting multiple sclerosis

Clinics, 2013
OBJECTIVE: The aim of this study was to characterize the microscopic damage to the corpus callosum in relapsing-remitting multiple sclerosis (RRMS) with diffusion tensor imaging and to investigate the correlation of this damage with disability.
Carolina de Medeiros Rimkus, Thiago de Faria Junqueira, Dagoberto Callegaro, Maria Concepcion Garcia Otaduy, Claudia da Costa Leite   +4 more
doaj   +1 more source

Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging

Neural Regeneration Research, 2022
Multiple sclerosis is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention, memory, and the speed of information processing.
Xin-Quan Gu, Ying Liu, Jie-Bing Gu, Lin-Fang Li, Ling-Ling Fu, Xue-Mei Han   +5 more
doaj   +1 more source