Results 61 to 70 of about 41,565 (267)

SWiss Atorvastatin and Interferon Beta-1b Trial In Multiple Sclerosis (SWABIMS) - rationale, design and methodology

Trials, 2009
Background Statins have anti-inflammatory and immunomodulatory properties in addition to their lipid-lowering effects. Currently, the effects of statins on multiple sclerosis are still controversial.
Mattle Heinrich P, Kamm Christian P
doaj   +1 more source

Experiences of Relapsing Remitting Multiple Sclerosis and Disease Modifying Treatment: A phenomenological inquiry [PDF]

A review of the body of knowledge has provided an insightful overview of the significant strides taken in the field of multiple sclerosis. For instance, the literature has made clear the considerable impact this autoimmune disease can have on an ...
Patel, Dipesh
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Comparison some of the syntactic skills in Relapsing Remitting Multiple sclerosis and normal adults resident in Esfahan Province

مجله پژوهش در علوم توانبخشی, 2013
Introduction: Multiple sclerosis is a progressive disease of the central nervous system that deteriorates myelin sheath and produce plaques in white matters of the brain and spinal cord.
Sedigheh Jamalpour, Nahid Baharlooie, Fereshteh Ashtari, Fereshteh Shamsian, Morteza Sedehi   +4 more
doaj   +1 more source

Neural correlates of alerting and orienting impairment in multiple sclerosis patients. [PDF]

PLoS ONE, 2014
BackgroundA considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied.
Manuel Vázquez-Marrufo, Alejandro Galvao-Carmona, Javier J González-Rosa, Antonio R Hidalgo-Muñoz, Mónica Borges, Juan Luis Ruiz-Peña, Guillermo Izquierdo   +6 more
doaj   +1 more source

ACCLAIM: A randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis [PDF]

, 2017
Background: Costimulatory blockade of T lymphocytes with the CTLA4-Ig fusion protein abatacept could be an effective treatment for the immune-mediated neuroinflammatory disease relapsing-remitting multiple sclerosis (RRMS).
Smilek, Dawn Elaine, Freedman, Mark Steven, Margie Byron, Mark S Freedman, Wendy Gao, Ryker, Kristin, Sayre, Peter H., Linna Ding, Samia J Khoury, Patti Tosta, Peter H Sayre, James Rochon, Byron, Margie, Arnold, Douglas L., Khoury, Samia J., Kristin Ryker, Tosta, Patti, Rochon, James J., Gao, Wendy, Douglas L Arnold, Dawn E Smilek, Ding, Linna   +21 more
core   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Heart rate variability is differentially altered in multiple sclerosis: implications for acute, worsening and progressive disability

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2017
Background Sympathovagal imbalance has been associated with poor prognosis in chronic diseases, but there is conflicting evidence in multiple sclerosis.
Valeria Studer, Camilla Rocchi, Caterina Motta, Benedetta Lauretti, Jacopo Perugini, Laura Brambilla, Lorena Pareja-Gutierrez, Giorgia Camera, Francesca Romana Barbieri, Girolama A Marfia, Diego Centonze, Silvia Rossi   +11 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source