Results 71 to 80 of about 41,565 (267)

Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency

Allergy, Asthma & Clinical Immunology, 2018
Background Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune ...
Leisa Rebecca Watson, Charlotte A. Slade, Samar Ojaimi, Sara Barnes, Pasquale Fedele, Prudence Smith, Justine Marum, Sebastian Lunke, Zornitza Stark, Matthew F. Hunter, Vanessa L. Bryant, Michael Sze Yuan Low   +11 more
doaj   +1 more source

Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis. [PDF]

, 2010
The objective was to test three motor system-specific hypotheses in multiple sclerosis patients: (i) corticospinal tract and primary motor cortex imaging measures differ between multiple sclerosis patients and controls; (ii) in patients, these measures ...
Ciccarelli, Olga, Thompson, Alan J, Gorgoraptis, Nikos, Wheeler-Kingshott, Claudia AM, Altmann, Daniel R, Jenkins, Thomas M, Miller, David H   +6 more
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Examining the link between information processing speed and executive functioning in multiple sclerosis

, 2009
Slowed information processing speed (IPS) is frequently reported in those with multiple sclerosis (MS), and at least 20% are compromised on some aspect of executive functioning also.
Drew, Margaret A., Margaret A. Drew, Nicola J. Starkey, Robert B. Isler, Starkey, Nicola J., Isler, Robert B.   +5 more
core   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis

, 2006
Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator ...
Prinster, Anna
core  

Comparative analysis of fingolimod versus teriflunomide in relapsing-remitting multiple sclerosis

, 2019
Background: Fingolimod and teriflunomide are commonly used in the treatment of relapsing-remitting multiple sclerosis (RRMS). These have not been compared in controlled trials, but only in observational studies, with inconclusive results.
YÜCEYAR, AYŞE NUR, Balci, Belgin Petek, Yüceyar, Nur, Gözübatik Çelik, Gökçen, TERZİ, MURAT, EKMEKCİ, ÖZGÜL, Ozer, Bilge, Karahan, Serap Zengin, Demirkiran, Meltem, Koseoglu, Mesrure, Sevim, Serhan, ÖZAKBAŞ, SERKAN, Turkoglu, Recai, GozubatikCelik, Gokcen, Altunrende, Burcu, Soysal, Aysun, Demirkıran, Meltem, KARABUDAK, RANA, Akman, Gulsen, EFENDİ, HÜSNÜ, Kale, Nilufer, BOZ, CAVİT, TURAN, ÖMER FARUK, Kurne, Aslı, AKÇALI, AYLİN, Kurne, Asli, Altintas, Ayse   +26 more
core   +1 more source

Clinical Predictors of Response in Chronic Graft‐Versus‐Host Disease: Results From the “Predicting the Quality of Response to Specific Treatments (PQRST)” Trial

American Journal of Hematology, EarlyView.
ABSTRACT Despite significant progress in chronic GVHD therapies, challenges remain in understanding pleomorphic phenotypes and varying responses to treatment. The aim of this study was to identify predictors of treatment response. We conducted a prospective, observational cohort study of patients beginning first‐, second‐, or third‐line systemic ...
Betty K. Hamilton, Lynn Onstad, Paul A. Carpenter, Joseph Pidala, George Chen, Corey Cutler, Najla El Jurdi, Nosha Farhadfar, Mark Juckett, Carrie L. Kitko, Catherine J. Lee, Stephanie J. Lee   +11 more
wiley   +1 more source

Role of oral teriflunomide in the management of multiple sclerosis

Neuropsychiatric Disease and Treatment, 2013
Radu Tanasescu,1,2 Nikos Evangelou,1 Cris S Constantinescu1 1Academic Division of Clinical Neurology, University of Nottingham, Nottingham, UK; 2Department of Neurology, Colentina Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest ...
Tanasescu R, Evangelou N, Constantinescu CS   +2 more
doaj  

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source