Results 61 to 70 of about 1,799,214 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Data Processing, 1982 It is well known that the growth in demands from end users for new applications is outstripping the capability of data processing departments to implement the corresponding application programs. There are two complementary approaches to attacking this problem (and both approaches are needed): one is to put end users into direct touch with the ...
openaire +3 more sources
Bipolarity in the querying of temporal databases [PDF]
, 2013 A database represents part of reality by containing data representing properties of real objects or concepts. To many real-world concepts or objects, time is an essential aspect and thus it should often be (implicitly) represented by databases, making ...
Billiet, Christophe +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The effects of water quality on freshwater fish populations - final report [PDF]
, 1990 There is a need to determine quantitative relationships between fishery status and water quality in order to make informed judgements concerning fishery health and the setting of environmental quality standards for fishery protection.
Gulson, J., Mainstone, C.P.
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
A Methodology for Vertically Partitioning in a Multi-Relation Database Environment
Journal of Computer Science and Technology, 2007 Vertical partitioning, in which attributes of a relation are assigned to partitions, is aimed at improving database performance. We extend previous research that is based on a single relation to multi-relation database environment, by including ...
Narasimhaiah Gorla
doaj
PLoS ONE, 2021 A fundamental premise of river management is that practitioners understand the resource they are working with. In river management this requires that baseline information is available on the structure, function, health and trajectory of rivers.
Kirstie Fryirs +7 more
doaj +1 more source
ALIA LIS research environmental scan report [PDF]
, 2014 Executive summary: An environmental scan of Australian Library and Information Studies (LIS) research was undertaken focusing on the period 2005–2013.
Christine Yates, Michael Middleton
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source