Results 71 to 80 of about 3,444 (218)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Reformulated Multiple Shear Mechanism Model for Fast 3D Nonlinear Ground Motion Analysis
GeosciencesWe have proposed the reduction in triple integral to double integral that is used in multiple shear mechanism model for faster 3D nonlinear ground motion analysis.
Yoshihiro Shishikura +2 more
doaj +1 more source
INDEXES SELECTION FOR BLOCKS OF RELATED SQL QUERIES [PDF]
Applied Computer Science, 2012 This paper discusses the problem of minimizing the response time for a given database workload by a proper choice of indexes. The main objective of our contribution is to illustrate the database queries as a group and search for good indexes for the ...
Radosław BOROŃSKI
doaj
Data in Brief, 2019 The SEAMIS database (Mendeley data repository; https://doi.org/10.17632/wp4ctb4667.1) contains 546 relative sea-level indicators from 31 different studies within the broader Southeast Asian region including the Maldives, India and Sri Lanka.
Thomas Mann +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Multilevel Package Identification Scheme Based on RFID Code and Related Package Message
International Journal of Distributed Sensor Networks, 2016 Radio Frequency Identification (RFID) is one of the key areas of the internet of things (IoT) and widely used in the fields of target identification, security, tracking, anticounterfeiting, and so forth.
Yanghua Gao +3 more
doaj +1 more source
IEEE Access, 2018 Selecting the most suitable local invariant feature detector for a particular application has rendered the task of evaluating feature detectors a critical issue in vision research. Although the literature, offers a variety of comparison works focusing on
Bruno Ferrarini +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source