Results 61 to 70 of about 1,807,111 (288)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Data Processing, 1982 It is well known that the growth in demands from end users for new applications is outstripping the capability of data processing departments to implement the corresponding application programs. There are two complementary approaches to attacking this problem (and both approaches are needed): one is to put end users into direct touch with the ...
openaire +3 more sources
The effects of water quality on freshwater fish populations - final report [PDF]
, 1990 There is a need to determine quantitative relationships between fishery status and water quality in order to make informed judgements concerning fishery health and the setting of environmental quality standards for fishery protection.
Gulson, J., Mainstone, C.P.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Methodology for Vertically Partitioning in a Multi-Relation Database Environment
Journal of Computer Science and Technology, 2007 Vertical partitioning, in which attributes of a relation are assigned to partitions, is aimed at improving database performance. We extend previous research that is based on a single relation to multi-relation database environment, by including ...
Narasimhaiah Gorla
doaj
PLoS ONE, 2021 A fundamental premise of river management is that practitioners understand the resource they are working with. In river management this requires that baseline information is available on the structure, function, health and trajectory of rivers.
Kirstie Fryirs +7 more
doaj +1 more source
Visualization of Simultaneous Localization and Mapping using SVG [PDF]
, 2013 Robotic system often use simultaneous localization and mapping method in their operations. Most of the calculation stored as a nested array with multiple level and dimension.
Dr. Achmad Widodo, ST, MT +2 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source