Results 61 to 70 of about 396,401 (266)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A relation merging technique for relational databases [PDF]
[1992] Eighth International Conference on Data Engineering, 2003 A merging technique for relational schemas consisting of relation-schemes, key dependencies, referential integrity constraints, and null constraints is presented. The author examines the conditions required for using this technique with relational database management systems that provide different mechanisms for maintaining null and referential ...
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
PLoS ONE, 2021 A fundamental premise of river management is that practitioners understand the resource they are working with. In river management this requires that baseline information is available on the structure, function, health and trajectory of rivers.
Kirstie Fryirs +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
BDHI: a French national database on historical floods
E3S Web of Conferences, 2016 The paper describes the various features of the BDHI database (objects, functions, content). This document database provides document sheets on historical floods from various sources: technical reports from water authorities, scientific accounts ...
Lang Michel +4 more
doaj +1 more source
Workforce information database system to support production planning in construction projects
Journal of Civil Engineering and Management, 2012 Information on the capacity of available workforce is important in production planning because a production unit's quantitative and qualitative capacities need to match its assigned loads. In the planning process, assigned loads and quantitative capacity
Sang-Chul Kim, Yong-Woo Kim
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
NanoBase: a tiny relation database manager for the JME CLDC/MIDP Platform
Revista Tecnologia, 2009 Os recentes avanços obtidos na tecnologia de computação móvel possibilitam o desenvolvimento de novas e sofisticadas aplicações, as quais podem agora armazenar dados no próprio dispositivo móvel. A plataforma JME vem se consolidando como um padrão para
Leonardo Eloy +3 more
doaj