Results 81 to 90 of about 1,807,111 (288)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
PURE: a Prompt-based framework with dynamic Update mechanism for educational Relation Extraction
Complex & Intelligent SystemsTraditional education systems obscure the diverse interconnections inherent within subject knowledge, thus failing to meet the current demand for personalized and adaptive learning experiences.
Xiaohui Cui +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
An Interoperable Cartographic Database
Kartografija i Geoinformacije, 2007 The concept of producing a prototype of interoperable cartographic database is explored in this paper, including the possibilities of integration of different geospatial data into the database management system and their visualization on the Internet ...
Slobodanka Ključanin, Zdravko Galić
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Progress on Sanitation and Drinking-Water 2010 Update [PDF]
, 2010 This report by the WHO/UNICEF Joint Monitoring Program for Water Supply and Sanitation (JMP) confirms that advances continue to be made towards greater access to safe drinking-water.
core
Database Slicing on Relational Databases
Acta Cybernetica, 2014 Many software systems today use databases to permanently store their data. Testing, bug finding and migration are complex problems in the case of databases that contain many records. Here, our method can speed up these processes if we can select a smaller piece of the database (called a slice) that contains all of the records belonging to the slicing ...
Dávid Tengeri, Ferenc Havasi
openaire +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Reformulated Multiple Shear Mechanism Model for Fast 3D Nonlinear Ground Motion Analysis
GeosciencesWe have proposed the reduction in triple integral to double integral that is used in multiple shear mechanism model for faster 3D nonlinear ground motion analysis.
Yoshihiro Shishikura +2 more
doaj +1 more source
INDEXES SELECTION FOR BLOCKS OF RELATED SQL QUERIES [PDF]
Applied Computer Science, 2012 This paper discusses the problem of minimizing the response time for a given database workload by a proper choice of indexes. The main objective of our contribution is to illustrate the database queries as a group and search for good indexes for the ...
Radosław BOROŃSKI
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