Results 81 to 90 of about 3,444 (218)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Characterization of a typology of exercises for the teaching of the Model Entity/Relationship
Revista MENDIVE, 2007 The creation process of a database crosses through a series of stages; one of them is the design. Inside this stage the data models play an important role.
Manuel Pereira Rosa
doaj
Factorisation in relational databases
, 2014 We study representation systems for relational data based on relational algebra expressions with unions, products, and singleton relations. Algebraic factorisation using the distributivity of product over union allows succinct representation of many-to-many relationships; further succinctness is brought by sharing repeated subexpressions.
openaire +2 more sources
Relational Databases and Bell’s Theorem [PDF]
, 2013 Our aim in this paper is to point out a surprising formal connection, between two topics which seem on face value to have nothing to do with each other: relational database theory, and the study of non-locality and contextuality in the foundations of quantum mechanics.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Derivation of constraints and database relations
, 1996 In this paper we investigate which constraints may be derived from a given set of constraints. We show that, given a set of relations R, all of which are invariant under some set of permutations P, it is possible to derive any other relation which is invariant under P, using only the projection, Cartesian product, and selection operators, together with
David A. Cohen +2 more
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
DATABASE RELATIONS AND BORLANDDELPHI
, 2019 Database is a set of data that has been arranged in such a way with certain provisions or rules that are interconnected so that it makes it easier for users to manage it, and Delphi provides complete facilities for processing databases. Various database formats.
openaire +3 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source