Results 61 to 70 of about 390,747 (230)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Trend Analysis of Temperature and Humidity in Kwara State, Nigeria
Journal of Environmental Geography, 2020 This paper examines the trend analysis of temperature and relative humidity in Kwara State. Climatic data on annual mean temperature (minimum and maximum) and relative humidity for 40 years (1978-2017) were collected from Nigerian Meteorological Agency ...
Adedapo Adeniyi
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A Low-Cost Humidity Control System to Protect Microscopes in a Tropical Climate
Annals of Global Health, 2020 Introduction: A clean and functional microscope is necessary for accurate diagnosis of infectious diseases. In tropical climates, high humidity levels and improper storage conditions allow for the accumulation of debris and fungus on the optical ...
Anders J. Asp +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The effect of load and relative humidity on bending creep behaviour of hornbeam in three altitudes (Case Study, Nowshahr Meshelak Branch) [PDF]
Iranian Journal of Wood and Paper Industries, 2018 For this purpose, 9 hornbeam trees at 400, 800 and 1100 meters altitude from forestry projects of Meshelak Nowshahr were selected. 324 Clear samples were cut at mature wood in diameter breast height (DBH).
Valiullah Mousavi +2 more
doaj
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Opposite Trends in Light Rain Days over Western and Eastern China from 1960 to 2014
Atmosphere, 2017 In this work, we examined spatial and temporal trends for light rain days based on daily precipitation measurements, obtained from 1960 to 2014, from 590 meteorological stations in China. For the analyzed time interval, light rain days over eastern China
Shikai Song, Changqing Jing, Zengyun Hu
doaj +1 more source