Results 71 to 80 of about 3,273,882 (269)

A Case Study of Assimilating Lightning-Proxy Relative Humidity with WRF-3DVAR

open access: yesAtmosphere, 2017
Lightning network data, considered as a useful supplement to radar observations, are a good indicator of severe convection, and has high temporal and spatial resolution.
Ying Wang   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Long-term trend of air humidity over China in the context of global warming during 1961—2010

open access: yesShui kexue jinzhan, 2020
Air humidity is one of the most important meteorological elements, which is closely related to the temperature and precipitation. Long-term trend of air humidity reflects the change of climate system.
Yun XIE   +4 more
doaj   +1 more source

Bond Strength of Resin Composite to Dentin with Different Adhesive Systems: Influence of Relative Humidity and Application Time. [PDF]

open access: yes, 2015
PURPOSE To investigate the influence of relative humidity and application time on bond strength to dentin of different classes of adhesive systems.
Amsler, Fabienne   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Roles Of Relative Humidity On Songda Typhoon 2011 Intensity

open access: yes, 2014
The objectives of the research were to investigate the influences of relative humidity as well as its changes on Songda Typhoon intensity. Advanced Research of Weather Research and Forecasting (AR-WRF) with three scenarios were implemented in the ...
Ahmad Bey, Yopi Ilhamsyah, Edvin Aldrian
core  

Measurements of Light Extinction by Single Aerosol Particles [PDF]

open access: yes, 2013
A Bessel beam optical trap is combined with continuous wave cavity ringdown spectroscopy to measure the extinction cross section of individual aerosol particles.
Reid, Jonathan P.   +3 more
core   +1 more source

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