Results 31 to 40 of about 62,456 (245)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fault-tolerant relative navigation based on Kullback–Leibler divergence

International Journal of Advanced Robotic Systems, 2020
A fault-detection method for relative navigation based on Kullback–Leibler divergence (KLD) is proposed. Different from the traditional χ 2 -based approaches, the KLD for a filter is following a hybrid distribution that combines χ 2 distribution and F ...
Jun Xiong, Joon Wayn Cheong, Zhi Xiong, Andrew G Dempster, Shiwei Tian, Rong Wang, Jianye Liu   +6 more
doaj   +1 more source

Observability Analysis and Navigation Filter Optimization of High-Orbit Satellite Navigation System Based on GNSS

Applied Sciences, 2020
Global Navigation Satellite System (GNSS) can be applied for the navigation of the high-orbit satellites. The system observability will change due to the changes in the visible satellite numbers and the spatial geometry between the navigation satellites ...
Yaqi Xiao, Xuanying Zhou, Jiongqi Wang, Zhangming He, Haiyin Zhou   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Model-Based Tracking in a Space-Simulated Environment Using the General Loss Function

Aerospace
The increasing demand for on-orbit servicing (OOS), such as satellite life extension and space debris removal, has highlighted the need for research into precise relative navigation between space objects.
Seongho Lee, Geemoon Noh, Jihoon Park, Hyeonik Kwon, Jaedu Park, Daewoo Lee   +5 more
doaj   +1 more source

A Dual Grid Collaborative Navigation Method and Computer Simulation Based on Data Link [PDF]

Hangkong bingqi
In response to the demand for relative/absolute navigation positioning in combat formation cooperative operations under GNSS-denied environment, a dual grid collaborative navigation method based on data link is proposed.
Li Yongfeng, Hao Xiuqiang, Wu Zhenguo, Wu Gang, Guo Chubing
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An Efficient Multi-AUV Cooperative Navigation Method Based on Hierarchical Reinforcement Learning

Journal of Marine Science and Engineering, 2023
Positioning errors introduced by low-precision navigation devices can affect the overall accuracy of a positioning system. To address this issue, this paper proposes a master-slave multi-AUV collaborative navigation method based on hierarchical ...
Zixiao Zhu, Lichuan Zhang, Lu Liu, Dongwei Wu, Shuchang Bai, Ranzhen Ren, Wenlong Geng   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source